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Cholestatic liver disease can be subdivided into different types according to its clinical phenotype, such as biliary atresia, drug\u2010induced cholestasis, gallstone liver disease, intrahepatic cholestasis of pregnancy, primary biliary cholangitis and primary sclerosing cholangitis. Considerable effort has been devoted to elucidating underlying mechanisms of cholestatic liver injuries and explore novel therapeutic and diagnostic strategies using animal models. Animal models employed according to their appropriate applicability domain herein play a crucial role. This review provides an overview of currently available in vivo animal models, fit\u2010for\u2010purpose in modelling different types of cholestatic liver diseases. 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