{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:28:24Z","timestamp":1791912504362,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T00:00:00Z","timestamp":1613433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Nucleotides with add\u2010on interferon treatment (NUC\u2010IFN) provide significantly higher rates of hepatitis B surface antigen (HBsAg) loss in patients with chronic hepatitis B (CHB). This study aimed to investigate the sustainability of HBsAg loss and the prevention of clinical relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with CHB who achieved HBsAg loss and HBV DNA levels &lt;20\u00a0IU\/ml after IFN or NUC\u2010IFN therapy were enrolled and followed up for 96\u00a0weeks. The primary outcome was HBsAg negativity without viremia at week 96. Secondary outcomes included virological or clinical relapse and predictors of relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>420 patients were included in intention\u2010to\u2010treat analysis with 290 and 130 in the IFN and NUC\u2010IFN groups respectively. At week 96, the intention\u2010to\u2010treat analysis revealed similar outcomes between groups, including HBsAg seroreversion (24.83% vs. 23.08%, <jats:italic>P\u00a0<\/jats:italic>=\u00a0.70), viremia (16.90% vs 13.08%, <jats:italic>P\u00a0<\/jats:italic>=\u00a0.32) and clinical relapse (11.38% vs 10.00%, <jats:italic>P\u00a0<\/jats:italic>=\u00a0.68); the per\u2010protocol analyses also showed HBsAg seroreversion, viremia and clinical relapse in IFN group (15.50%, 6.59% and 0.39%) did not differ from those in NUC\u2010IFN group (15.25%, 4.24% and 0.85%, <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). These outcomes were similar between patients who received entecavir and those who received telbivudine\/lamivudine\/adefovir before the combination therapy. In NUC\u2010IFN\u2010treated patients, fibrosis regression was observed at week 96. Baseline HBsAb negativity was independent predictors of HBsAg sero\u2010reversion and recurrence of viremia in IFN treated group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NUC\u2010IFN and IFN therapies are equally effective in achieving sustained functional cure and fibrosis regression. (ClinicalTrials.gov, Number NCT02336399).<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14801","type":"journal-article","created":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T16:36:27Z","timestamp":1611506187000},"page":"1498-1508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Outcome of Chinese patients with hepatitis B at 96 weeks after functional cure with IFN versus combination regimens"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3723-6688","authenticated-orcid":false,"given":"Calvin Q.","family":"Pan","sequence":"first","affiliation":[{"name":"Center of Liver Diseases Beijing Ditan Hospital Capital Medical University Beijing China"},{"name":"Division of Gastroenterology and Hepatology Department of Medicine NYU Langone Health, New York University School of Medicine New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3233-5473","authenticated-orcid":false,"given":"Ming\u2010Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatology Division 2 Beijing Ditan Hospital Capital Medical University Beijing China"},{"name":"Department of Hepatology Division 2 Peking University Ditan Teaching Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4241-8205","authenticated-orcid":false,"given":"Wei","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3644-5306","authenticated-orcid":false,"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatology Division 2 Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3422-0082","authenticated-orcid":false,"given":"Yao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hepatology Division 2 Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Xiao","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Hepatology Division 2 Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Medical and Biological Statistics Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Hua","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Hepatology Division 2 Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing\u2010Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatology Division 2 Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong\u2010Ping","family":"Ran","sequence":"additional","affiliation":[{"name":"Department of Hepatology Division 2 Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Hepatology Division 2 Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hepatology Division 2 Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Hepatology Division 2 Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Jiao","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Hepatology Division 2 Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4108-7037","authenticated-orcid":false,"given":"Yao","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Hepatology Division 2 Beijing Ditan Hospital Capital Medical University Beijing China"},{"name":"Department of Hepatology Division 2 Peking University Ditan Teaching Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1508660"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.2.36"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14577"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2481"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12738"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i18.5524"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.03.016"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.09.018"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13779"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00249-15"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.031"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29323"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.021"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-015-1153-1"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24715"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-016-0454-z"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307237"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3256"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28156"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14629"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.03.006"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12121"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2003.00450.x"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.14801","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/liv.14801","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.14801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T17:37:21Z","timestamp":1693417041000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.14801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,16]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/liv.14801"],"URL":"https:\/\/doi.org\/10.1111\/liv.14801","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,16]]},"assertion":[{"value":"2019-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}