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This study aimed to evaluate the long\u2010term effects of two personalized energy\u2010restricted dietary strategies on weight loss, metabolic and hepatic outcomes in overweight\/obese subjects with NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010eight subjects from the Fatty Liver in Obesity (FLiO) study (NCT03183193) were randomly assigned to the American Heart Association (AHA) or the FLiO dietary group in a 2\u2010year controlled trial. Anthropometry, body composition (DXA), biochemical parameters and hepatic status (ultrasonography, Magnetic Resonance Imaging, and elastography) were assessed at baseline, 6, 12 and 24\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both the AHA and FLiO diets significantly reduced body weight at 6 (\u22129.7% vs \u221210.1%), 12 (\u22126.7% vs \u22129.6%), and 24\u00a0months (\u22124.8% vs \u22127.6%) with significant improvements in body composition, biochemical and liver determinations throughout the intervention. At the end of the follow\u2010up, the FLiO group\u00a0showed a greater decrease in ALT, liver stiffness and Fatty Liver Index, among others, compared\u00a0to AHA group, although these differences were attenuated when the analyses were adjusted by weight loss percentage. The FLiO group also showed a greater increase in adiponectin compared to AHA group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The AHA and FLiO diets were able to improve body weight and body composition, as well as metabolic and hepatic status of participants with overweight\/obesity and NAFLD within a 2\u2010year follow\u2010up. These findings show that both strategies are suitable alternatives for NAFLD management. However, the FLiO strategy may provide more persistent benefits in metabolic and hepatic parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14818","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T19:28:38Z","timestamp":1612812518000},"page":"1532-1544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Effects of two personalized dietary strategies during a 2\u2010year intervention in subjects with nonalcoholic fatty liver disease: A randomized trial"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0741-8197","authenticated-orcid":false,"given":"Bertha A.","family":"Marin\u2010Alejandre","sequence":"first","affiliation":[{"name":"Department of Nutrition Food Sciences and Physiology and Centre for Nutrition Research Faculty of Pharmacy and Nutrition University of Navarra Pamplona 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