{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:07:44Z","timestamp":1754107664781,"version":"3.40.5"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T00:00:00Z","timestamp":1614470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite universal health coverage in France, migrants face specific socioeconomic barriers that increase the likelihood of a suboptimal cascade of care for chronic hepatitis C virus (HCV) infection and impaired treatment effectiveness in this sub\u2010population. We selected data collected from 2012 to 2018 from the ANRS CO22 HEPATHER prospective cohort study for chronic HCV participants with available data on treatment failure (defined as the presence of a detectable HCV\u2010RNA load 12\u00a0weeks after their first DAA treatment ended). We performed multivariable Poisson regression models to test whether treatment failure rates differed significantly between HCV\u2010infected migrants and non\u2010migrants receiving DAA in France (cross\u2010sectional analysis), while taking into account the former's world region of birth and other potential social vulnerability factors. Among the study population's 7,879 patients, 5,829 (74%) were non\u2010migrants and 2,050 (26%) migrants. Median [interquartile range] age was 57 [51\u201065] years, 4433 (56%) were men and 369 (5%) of the entire study population had treatment failure. After multivariable adjustment, only migrants from Central Asia were at higher risk of treatment failure than non\u2010migrants (aIRR\u00a0=\u00a02.83; 95% CI [1.72, 4.65]). Results from this large\u2010scale study performed in France suggest a higher risk of DAA treatment failure in migrants from Central Asia than in non\u2010migrants and confirm the overall low treatment failure rate in chronic HCV patients treated with DAA (whether migrants or not). Simplified models of care taking into account language and cultural barriers are needed to improve DAA effectiveness in migrants from Central Asia.<\/jats:p>","DOI":"10.1111\/liv.14823","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T20:49:48Z","timestamp":1613681388000},"page":"2328-2340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effectiveness of direct\u2010acting antivirals for chronic hepatitis C treatment in migrant and non\u2010migrant populations in France"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3000-5243","authenticated-orcid":false,"given":"Tchadine","family":"Djaogol","sequence":"first","affiliation":[{"name":"Aix Marseille Univ INSERM IRD SESSTIM Sciences Economiques &amp; Sociales de la Sant\u00e9 &amp; Traitement de l\u2019Information M\u00e9dicale Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4853-1786","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes AP\u2010HP Unit\u00e9 d'H\u00e9patologie H\u00f4pital Cochin INSERM U\u2010818 et USM20 Institut Pasteur Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u00ebl","family":"Baudoin","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ INSERM IRD SESSTIM Sciences Economiques &amp; 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Sociales de la Sant\u00e9 &amp; Traitement de l\u2019Information M\u00e9dicale Marseille France"},{"name":"ORS PACA Observatoire r\u00e9gional de la sant\u00e9 Provence\u2010Alpes\u2010C\u00f4te d\u2019Azur Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Dorival","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9 INSERM Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9lanie","family":"Simony","sequence":"additional","affiliation":[{"name":"ANRS (France Recherche Nord &amp; Sud Sida\u2010HIV H\u00e9patites) Unit for Basic and Clinical Research on Viral Hepatitis Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8171-5416","authenticated-orcid":false,"given":"Ventzislava","family":"Petrov\u2010Sanchez","sequence":"additional","affiliation":[{"name":"ANRS (France Recherche Nord &amp; Sud Sida\u2010HIV H\u00e9patites) Unit for Basic and Clinical Research on Viral Hepatitis Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Bourli\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology H\u00f4pital Saint Joseph Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5129-9300","authenticated-orcid":false,"given":"Elisabeth","family":"Delarocque\u2010Astagneau","sequence":"additional","affiliation":[{"name":"UMR1181 Biostatistique, Biomath\u00e9matique, Pharmaco\u2010\u00e9pid\u00e9miologie et Maladies Infectieuses (B2PHI) Institut Pasteur, Inserm, Universit\u00e9 de Versailles\u2010Saint\u2010Quentin\u2010en\u2010Yvelines (UVSQ) Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislas","family":"Pol","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Descartes AP\u2010HP Unit\u00e9 d'H\u00e9patologie H\u00f4pital Cochin INSERM U\u2010818 et USM20 Institut Pasteur Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8672-7918","authenticated-orcid":false,"given":"Fabrice","family":"Carrat","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9 INSERM Institut Pierre Louis d\u2019Epid\u00e9miologie et de Sant\u00e9 Publique Paris France"},{"name":"AP\u2010HP H\u00f4pital Saint Antoine Unit\u00e9 de Sant\u00e9 Publique Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6794-4837","authenticated-orcid":false,"given":"Patrizia","family":"Carrieri","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ INSERM IRD SESSTIM Sciences Economiques &amp; 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