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Recently, the definition of HRS type 1 has been updated and is now called HRS\u2010AKI.\u00a0This new definition reduces the risk of delaying HRS treatment and eliminates the need to establish a minimum creatinine cut\u2010off for the diagnosis of HRS\u2010AKI. From a pathophysiological point of view, newly identified mechanisms involved in the development of HRS are related to the inflammatory response, conditioning the development of extrahepatic organ dysfunction in patients with cirrhosis. One of the main challenges for the diagnosis of HRS is the validation of new biomarkers to obtain an early and differential diagnosis of kidney injury (eg HRS vs. ATN). Treatment of HRS is based on the use of vasoconstrictive agents in combination with albumin and terlipressin is the most widely used vasoconstrictor drug, with a high response rate. The effects of a continuous infusion of terlipressin at a dose of 2\u201012\u00a0mg\/day was similar to bolus administration, but with lower rates of adverse events. Finally, MELD\/MELD\u2010Na which includes creatinine as one of its main determinants gives AKI\u2010HRS patients priority on the waiting list (WL) for liver transplant (LT). However, the MELD and MELD\u2010Na scores are reduced in responding patients, resulting a longer waiting time in these patients than in non\u2010responders. Thus, the initial MELD\/MELD\u2010Na score (pre\u2010treatment value) should be used to prioritize patients on the WL for LT in these cases.<\/jats:p>","DOI":"10.1111\/liv.14866","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T05:38:49Z","timestamp":1624340329000},"page":"119-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["End\u2010stage liver disease: Management of hepatorenal syndrome"],"prefix":"10.1111","volume":"41","author":[{"given":"Ezequiel","family":"Mauro","sequence":"first","affiliation":[{"name":"Liver Unit Hospital Italiano de Buenos Aires Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucrecia","family":"Garcia\u2010Olveira","sequence":"additional","affiliation":[{"name":"Liver Unit Hospital Italiano de Buenos Aires Buenos Aires 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