{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T10:34:53Z","timestamp":1788690893589,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Autoimmune hepatitis (AIH) affects both sexes and all age groups. However, very few studies have focused specifically on the characteristics and outcome of AIH in patients aged 70\u00a0y or older.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>25\/234 patients with well\u2010established AIH and disease onset at \u226570\u2010y (median: 73\u2010y) were analysed and compared to the rest patients (median: 47\u00a0y). Treatment response was assessed in all patients from both groups who were eligible for treatment (n\u00a0=\u00a0202).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Disease presentation was mainly insidious in both groups (19\/25, 76% vs. 134\/209, 64.1%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.313). At diagnosis, older patients had lower alaninoaminotrasferase (101[433] vs. 199[441] IU\/L, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) but were more frequently cirrhotic (12\/25, 48% vs. 57\/209, 27.3%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). Importantly, similar rates of on\u2010treatment response (16\/18, 89% vs. 154\/184, 84%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.565), corticosteroid withdrawal (10\/16, 62.5% vs. 113\/154, 73.4%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.355) and complete withdrawal of immunosuppression (1\/16, 6.3% vs. 40\/154, 26%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.122) were achieved in both groups. Treatment\u2010related adverse events were evenly observed between groups (6\/18, 33% vs. 54\/184, 29%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.724). In treated patients, the age \u226570\u00a0y was only associated with the overall mortality (HR 8.3 [95% CI: 2.1\u201036.4], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003), but not with the liver\u2010related mortality (HR 3.4 [95% CI: 0.4\u201030.0], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.268).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AIH should be seriously considered in patients \u226570\u00a0y with unexplained impaired liver function tests as the disease is not infrequent in this group and seems to bear an increased risk for advanced disease stage at diagnosis. However, if immunosuppression is started promptly, it seems as safe and effective as in younger patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14900","type":"journal-article","created":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T09:14:25Z","timestamp":1619342065000},"page":"1592-1599","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Autoimmune hepatitis in patients aged 70 years or older: Disease characteristics, treatment response and outcome"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7075-8464","authenticated-orcid":false,"given":"George N.","family":"Dalekos","sequence":"first","affiliation":[{"name":"Department of Medicine and Research Laboratory of Internal Medicine National Expertise Center of Greece in Autoimmune Liver Diseases General University Hospital of Larissa Larissa Greece"},{"name":"Institute of Internal Medicine and Hepatology Larissa 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Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Gampeta","sequence":"additional","affiliation":[{"name":"Department of Medicine and Research Laboratory of Internal Medicine National Expertise Center of Greece in Autoimmune Liver Diseases General University Hospital of Larissa Larissa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos K.","family":"Gatselis","sequence":"additional","affiliation":[{"name":"Department of Medicine and Research Laboratory of Internal Medicine National Expertise Center of Greece in Autoimmune Liver Diseases General University Hospital of Larissa Larissa Greece"},{"name":"Institute of Internal Medicine and Hepatology Larissa 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