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HEV\u2010related clinical complications are often undetected and are not considered in the differential diagnosis. Convincing findings from studies suggest that HEV is clinically relevant not only in developing countries but also in industrialized countries. Eight HEV genotypes (HEV\u20101 to HEV\u20108) with different human and animal hosts and other HEV\u2010related viruses are in circulation. Transmission routes vary by genotype and location, with large waterborne outbreaks in developing countries and zoonotic food\u2010borne infections in developed countries. An acute infection can be aggravated in pregnant women, organ transplant recipients, patients with pre\u2010existing liver disease and immunosuppressed patients. HEV during pregnancy affects the fetus and newborn with an increased risk of vertical transmission, preterm and stillbirth, neonatal jaundice and miscarriage. 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