{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T10:49:30Z","timestamp":1792838970543,"version":"4.5.0"},"reference-count":13,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to assess the pregnancy outcome in women with chronic HCV who had negative pregnancy test prior to the anti\u2010HCV course and had unintended pregnancy while on HCV treatment. Hundred patients with a mean age of 30\u00a0\u00b1\u00a06.7\u00a0y were included and advised to withhold antivirals and continue follow\u2010up in viral hepatitis and obstetrics centres till delivery. All patients received a 12\u2010weeks regimen of anti\u2010HCV [sofosbuvir plus daclatasvir (SOF\/DCV): n\u00a0=\u00a095, SOF\/DCV plus ribavirin: n\u00a0=\u00a03, and paritaprevir\/ritonavir\/ombitasvir plus ribavirin: n\u00a0=\u00a02]. Only nine patients completed the full antiviral course against medical advice, and 91 stopped between on\u2010treatment weeks 4 and 8. Eighty\u2010eight patients delivered full\u2010term babies, eight had preterm babies and two had abortions. Of the nine patients who completed the full course of DAAs, seven (77.8%) delivered normal babies, attended their post\u2010treatment week 12 visit, and all (100%) achieved sustained virological response. No major antiviral\u2010related adverse events were reported.<\/jats:p>","DOI":"10.1111\/liv.14913","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T15:37:58Z","timestamp":1619537878000},"page":"1494-1497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Pregnancy outcome of anti\u2010HCV direct\u2010acting antivirals: Real\u2010life data from an Egyptian cohort"],"prefix":"10.1111","volume":"41","author":[{"given":"Mohamed","family":"AbdAllah","sequence":"first","affiliation":[{"name":"Medical Research Division National Research Center Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8490-9822","authenticated-orcid":false,"given":"Mohamed","family":"Alboraie","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Abdel\u2010Razek","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology National Liver Institute Menoufia University Menofyia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6001-8793","authenticated-orcid":false,"given":"Mohamed","family":"Hassany","sequence":"additional","affiliation":[{"name":"Department of Hepatology National Hepatology and Tropical Medicine Research Institute Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Islam","family":"Ammar","sequence":"additional","affiliation":[{"name":"Department of hepatology, gastroenterology and infectious diseases Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehab","family":"Kamal","sequence":"additional","affiliation":[{"name":"Medical Research Division National Research Center Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Alalfy","sequence":"additional","affiliation":[{"name":"Reproductive health and family planning department National Research Center Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0029-4577","authenticated-orcid":false,"given":"Ahmed","family":"Okasha","sequence":"additional","affiliation":[{"name":"Reproductive health and family planning department National Research Center Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafaa","family":"El Akel","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsaied","family":"Shaaban","sequence":"additional","affiliation":[{"name":"Internal medicine department El\u2010Mataria teaching hospital Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer","family":"Elbaz","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Hefny","sequence":"additional","affiliation":[{"name":"Tropical medicine department Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Gomaa","sequence":"additional","affiliation":[{"name":"Tropical Medicine Department Faculty of Medicine Fayoum University Fayoum Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3751-5927","authenticated-orcid":false,"given":"Mahmoud","family":"El\u2010Bendary","sequence":"additional","affiliation":[{"name":"Tropical Medicine and Hepatogastroenterology Mansoura Faculty of Medicine Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdy","family":"El\u2010Serafy","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamal","family":"Esmat","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wahid","family":"Doss","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatology Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal H","family":"El\u2010Sayed","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Clinical Research Center Faculty of Medicine Ain Shams University Cairo 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