{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T17:24:15Z","timestamp":1764350655233,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,30]],"date-time":"2021-05-30T00:00:00Z","timestamp":1622332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Glecaprevir\/pibrentasvir, a pangenotypic, direct\u2010acting antiviral combination approved for chronic hepatitis C virus treatment, has limited real\u2010world evidence supporting 8\u2010week therapy in compensated cirrhosis. We investigated effectiveness and safety of 187 hepatitis C virus\u2010infected, treatment\u2010na\u00efve, patients with compensated cirrhosis receiving 8\u2010week glecaprevir\/pibrentasvir therapy in the German Hepatitis C\u2010Registry between 2 August 2017 and 1 January 2020. Sustained virologic response was 98.4% (127\/129) in the per\u2010protocol analysis (excluding patients lost to follow\u2010up or who discontinued treatment due to compliance) and was 85.8% (127\/148) in patients with data available in an intention\u2010to\u2010treat analysis. Nineteen patients were lost to follow\u2010up; nine genotype 3 patients, nine nongenotype 3 patients and one mixed genotype patient. One patient relapsed, and one died, unrelated to treatment. Adverse events (&gt;5%) were fatigue and headache. Two serious adverse events occurred; no adverse events resulted in drug discontinuation. An 8\u2010week glecaprevir\/pibrentasvir therapy was effective and well\u2010tolerated in this real\u2010world analysis.<\/jats:p>","DOI":"10.1111\/liv.14937","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T10:35:50Z","timestamp":1620556550000},"page":"1518-1522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Glecaprevir\/pibrentasvir for 8\u00a0weeks in patients with compensated cirrhosis: Safety and effectiveness data from the German Hepatitis C\u2010Registry"],"prefix":"10.1111","volume":"41","author":[{"given":"Hartwig","family":"Klinker","sequence":"first","affiliation":[{"name":"University of W\u00fcrzburg Medical Center W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Naumann","sequence":"additional","affiliation":[{"name":"UBN\/Praxis Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"R\u00f6ssle","sequence":"additional","affiliation":[{"name":"PraxisZentrum f\u00fcr Gastroenterologie und Endokrinologie and University Hospital Freiburg Freiburg im Breisgau Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0003-6241","authenticated-orcid":false,"given":"Thomas","family":"Berg","sequence":"additional","affiliation":[{"name":"Division of Hepatology Department of Medicine Il Leipzig University Medical Center Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Bondin","sequence":"additional","affiliation":[{"name":"AbbVie Inc. North Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Lohmann","sequence":"additional","affiliation":[{"name":"AbbVie Deutschland GmbH and Co. KG Wiesbaden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Koenig","sequence":"additional","affiliation":[{"name":"AbbVie Deutschland GmbH and Co. KG Wiesbaden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Zeuzem","sequence":"additional","affiliation":[{"name":"Department of Medicine J.W. Goethe University Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9141-8001","authenticated-orcid":false,"given":"Markus","family":"Cornberg","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Endocrinology Hannover Medical School Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,30]]},"reference":[{"volume-title":"Global Hepatitis Report 2017","author":"World Health Organization","key":"e_1_2_12_2_1"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(16)30181-9"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62401-6"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.10.020"},{"volume-title":"Mavyret [US Package insert]","key":"e_1_2_12_6_1"},{"volume-title":"[Summary of Product Characteristics]","year":"2020","author":"Maviret EU","key":"e_1_2_12_7_1"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.08.018"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-020-01301-5"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.11.011"},{"key":"e_1_2_12_11_1","unstructured":"AASLD\u2010IDSA.Recommendations for testing managing and treating hepatitis C.https:\/\/www.hcvguidelines.org\/Revised November 6 2019. Accessed April 17 2020."},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15337"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14592"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2018.06.019"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa055"},{"issue":"2","key":"e_1_2_12_16_1","first-page":"195","article-title":"Direct\u2010acting antiviral treatment for chronic hepatitis C in people who use drugs in a real\u2010world setting","volume":"33","author":"Koustenis KR","year":"2020","journal-title":"Ann Gastroenterol"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy120"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2019.01.011"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2018.11.007"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.01.025"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.5114\/ceh.2019.88085"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.14937","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/liv.14937","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.14937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T17:38:11Z","timestamp":1693417091000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.14937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,30]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/liv.14937"],"URL":"https:\/\/doi.org\/10.1111\/liv.14937","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"type":"print","value":"1478-3223"},{"type":"electronic","value":"1478-3231"}],"subject":[],"published":{"date-parts":[[2021,5,30]]},"assertion":[{"value":"2020-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}