{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:37Z","timestamp":1787015737834,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003122","name":"Ferring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003122","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>MR elastography can determine organ\u2010related stiffness, which reflects the degree of fibrosis. Liver stiffness increases in cirrhosis, and stiffness increases further post\u2010prandially due to increased portal blood in\u2010flow. Non\u2010selective beta\u2010blockers (NSBB) reduce the portal venous inflow, but their effect on liver and spleen stiffness are disputed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess whether MR elastography of the liver or spleen reflects the severity of cirrhosis, whether treatment with NSBB changes liver and spleen stiffness and whether changes in stiffness can predict the effect of NSBB on portal pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty\u2010two patients with cirrhosis underwent liver vein catheterization and two\u2010dimensional (2D) MR elastography on separate days. Thirty\u2010six of the patients had a hepatic venous pressure gradient (HVPG) of \u226512\u00a0mmHg and were tested prior to, and after, intravenous infusion of NSBB using HVPG measurement and MR elastography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HVPG showed a strong, positive, linear relationship with liver stiffness (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.92;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) and spleen stiffness (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.94;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). The cut\u2010off points for identifying patients with a HVPG\u00a0\u2265\u00a012\u00a0mmHg were 7.7\u00a0kPa for liver stiffness (sensitivity 0.78, specificity 0.64) and 10.5\u00a0kPa for spleen stiffness (sensitivity 0.8, specificity 0.79).\n                    <\/jats:p>\n                    <jats:p>\n                      Intravenous administration of NSBB significantly decreased spleen stiffness by 6.9% (CI: 3.5\u201010.4,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), but NSBB had no consistent effect on liver stiffness. However, changes in spleen stiffness were not related to the HVPG response (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.75).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Two\u2010dimensional MR elastographic estimation of liver or spleen stiffness reflects the degree of portal hypertension in patients with liver cirrhosis, but changes in stiffness after NSBB do not predict the effect on HVPG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.14981","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T04:56:28Z","timestamp":1622523388000},"page":"2149-2158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Using MR elastography to assess portal hypertension and response to beta\u2010blockers in patients with cirrhosis"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7194-4541","authenticated-orcid":false,"given":"Karen Vagner","family":"Danielsen","sequence":"first","affiliation":[{"name":"Centre of Gastroenterology Medical Division Copenhagen University Hospital Hvidovre Hvidovre Denmark"},{"name":"Department of Clinical Physiology and Nuclear Medicine Centre of Functional and Diagnostic Imaging and Research Copenhagen University Hospital Hvidovre Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Dahlgaard","family":"Hove","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital Hvidovre Hvidovre Denmark"},{"name":"Institute of Clinical Medicine Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puria","family":"Nabilou","sequence":"additional","affiliation":[{"name":"Centre of Gastroenterology Medical Division Copenhagen University Hospital Hvidovre Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirabella","family":"Zhao","sequence":"additional","affiliation":[{"name":"Centre of Gastroenterology Medical Division Copenhagen University Hospital Hvidovre Hvidovre 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L.","family":"Ehman","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9684-7764","authenticated-orcid":false,"given":"S\u00f8ren","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Centre of Functional and Diagnostic Imaging and Research Copenhagen University Hospital Hvidovre Hvidovre Denmark"},{"name":"Institute of Clinical Medicine Faculty of Health Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flemming","family":"Bendtsen","sequence":"additional","affiliation":[{"name":"Centre of Gastroenterology Medical Division Copenhagen University Hospital Hvidovre Hvidovre Denmark"},{"name":"Institute of Clinical Medicine Faculty of Health Sciences University of Copenhagen Copenhagen 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