{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T17:39:45Z","timestamp":1788716385009,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T00:00:00Z","timestamp":1625875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>With the advent of low\u2010cost generic direct\u2010acting antivirals (DAA), hepatitis C (HCV) elimination is now achievable even in low\u2010\/middle\u2010income settings. We assessed the feasibility and effectiveness of a simplified clinical pathway using point\u2010of\u2010care diagnostic testing and non\u2010specialist\u2010led care in a decentralized, community\u2010based setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This feasibility study was conducted at two sites in Yangon, Myanmar: one for people who inject drugs (PWID), and the other for people with liver disease. Participants underwent on\u2010site rapid anti\u2010HCV testing and HCV RNA testing using GeneXpert\n                      <jats:sup>(R)<\/jats:sup>\n                      . General practitioners determined whether participants started DAA therapy immediately or required specialist evaluation. Primary outcome measures were progression through the HCV care cascade, including uptake of RNA testing and treatment, and treatment outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>All 633 participants underwent anti\u2010HCV testing; 606 (96%) were anti\u2010HCV positive and had HCV RNA testing. Of 606 tested, 535 (88%) were RNA positive and had pre\u2010treatment assessments; 30 (6%) completed specialist evaluation. Of 535 RNA positive participants, 489 (91%) were eligible to initiate DAAs, 477 (98%) completed DAA therapy and 421 achieved SVR12 (92%; 421\/456). Outcomes were similar by site: PWID site: 91% [146\/161], and liver disease site: 93% [275\/295]). Compensated cirrhotic patients were treated in the community; they achieved an SVR12 of 83% (19\/23). Median time from RNA test to DAA initiation was 3\u00a0days (IQR 2\u20105).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Delivering a simplified, non\u2010specialist\u2010led HCV treatment pathway in a decentralized community setting was feasible in Yangon, Myanmar; retention in care and treatment success rates were very high. This care model could be integral in scaling up HCV services in Myanmar and other low\u2010 and middle\u2010income settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.14983","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T12:22:10Z","timestamp":1624278130000},"page":"2578-2589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Outcomes of the CT2 study: A \u2018one\u2010stop\u2010shop\u2019 for community\u2010based hepatitis C testing and treatment in Yangon, Myanmar"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2624-2510","authenticated-orcid":false,"given":"Bridget Louise","family":"Draper","sequence":"first","affiliation":[{"name":"Disease Elimination Program Burnet Institute Melbourne Australia"},{"name":"School of Public Health and Preventive Medicine Monash University Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hla","family":"Htay","sequence":"additional","affiliation":[{"name":"Burnet Institute Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa","family":"Pedrana","sequence":"additional","affiliation":[{"name":"Disease Elimination Program Burnet Institute Melbourne Australia"},{"name":"School of Public Health and Preventive Medicine Monash University Melbourne Australia"},{"name":"Health Services Research and Implementation Monash Partners Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Win Lei","family":"Yee","sequence":"additional","affiliation":[{"name":"Burnet Institute Yangon Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Howell","sequence":"additional","affiliation":[{"name":"Disease Elimination Program Burnet Institute Melbourne Australia"},{"name":"School of Public Health and Preventive Medicine Monash University Melbourne Australia"},{"name":"St Vincent\u2019s Hospital Melbourne Australia"},{"name":"Department of Medicine University of Melbourne Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khin","family":"Pyone Kyi","sequence":"additional","affiliation":[{"name":"Myanmar Liver Foundation Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Win","family":"Naing","sequence":"additional","affiliation":[{"name":"Myanmar Liver Foundation Myanmar"},{"name":"Yangon Specialty Hospital Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khin","family":"Sanda Aung","sequence":"additional","affiliation":[{"name":"National Hepatitis Control Program, Ministry of Health and Sports Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Markby","sequence":"additional","affiliation":[{"name":"Foundation for Innovative New Diagnostics Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippa","family":"Easterbrook","sequence":"additional","affiliation":[{"name":"Department of Global HIV, Hepatitis, and STI Programmes World Health Organization Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bowring","sequence":"additional","affiliation":[{"name":"Disease Elimination Program Burnet Institute Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Win","family":"Aung","sequence":"additional","affiliation":[{"name":"Myanmar Liver Foundation Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Yi","family":"Sein","sequence":"additional","affiliation":[{"name":"Myanmar Liver Foundation Myanmar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nwe","family":"Nwe","sequence":"additional","affiliation":[{"name":"Foundation for Innovative New Diagnostics Geneva 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Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,10]]},"reference":[{"key":"e_1_2_14_2_1","unstructured":"World Health Organization (WHO).Global hepatitis report.2017.https:\/\/www.who.int\/hepatitis\/publications\/global\u2010hepatitis\u2010report2017\/en\/"},{"key":"e_1_2_14_3_1","unstructured":"World Health Organization (WHO).Global Health sector strategy on viral hepatitis 2016\u20132021.2016.https:\/\/www.who.int\/hepatitis\/strategy2016\u20102021\/ghss\u2010hep\/en\/"},{"key":"e_1_2_14_4_1","unstructured":"Center for Disease Analysis Foundation.Polaris observatory\u2014HCV elimination maps.https:\/\/cdafound.org\/dashboard\/polaris\/maps.html"},{"key":"e_1_2_14_5_1","unstructured":"World Health Organization (WHO).Progress report on access to hepatitis C treatment: focus on overcoming barriers in low\u2010 and middle\u2010income 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