{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:42:34Z","timestamp":1747186954862,"version":"3.40.5"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008266","name":"K\u00f8bmand I Odense Johan og Hanne Weimann F\u00f8dt Seedorffs Legat","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Shortening the treatment duration for chronic hepatitis C may increase feasibility and reduce the cost of cure. The aims of this study were to compare 4\u00a0weeks of glecaprevir\/pibrentasvir (GLE\/PIB) treatment with and without ribavirin for patients with chronic hepatitis C and favourable baseline characteristics and to monitor the development of resistance\u2010associated substitutions (RAS) and re\u2010treatment outcomes if treatment failed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed an open\u2010label single\u2010centre randomized controlled trial, in which patients with chronic hepatitis C were randomized 1:1 to GLE\/PIB\u00a0\u00b1\u00a0ribavirin, stratified by genotype 3. The main inclusion criteria were treatment\u2010naive patients, aged 18\u201049 with all genotypes accepted, and absence of liver fibrosis, determined by liver stiffness measurement less than 8\u00a0kPa. Viral genome sequences were determined by deep sequencing at baseline and at the time of relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 32 patients started treatment. Sustained virological response at week 12 (SVR12) was 59% (10\/17) for GLE\/PIB without ribavirin and 73% (11\/15) for GLE\/PIB with ribavirin. Drug target\u2010specific NS5A RAS were detected at baseline for 45% (5\/11) of patients with treatment failure and for 14% (3\/21) of patients who achieved SVR12. Ten failure patients were retreated 12\u00a0weeks with sofosbuvir\u2010based regimens; all have been cured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this pilot study of 4\u2010week treatment with GLE\/PIB with and without ribavirin, we found that baseline RAS were more frequent in patients with virological failure. Development of RAS did occur after short treatment but did not result in retreatment failure with a different regimen.<\/jats:p><jats:p><jats:bold>EudraCT no<\/jats:bold>: 2017\u2010005179\u201021.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.14991","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T16:05:55Z","timestamp":1624291555000},"page":"2601-2610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Inferior cure rate in pilot study of 4\u2010week glecaprevir\/pibrentasvir treatment with or without ribavirin of chronic hepatitis C"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7864-1268","authenticated-orcid":false,"given":"Lone W.","family":"Madsen","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Odense University Hospital Odense Denmark"},{"name":"OPEN Odense Patient data Explorative Network Odense University Hospital Odense Denmark"},{"name":"Clinical Institute University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peer B.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Odense University Hospital Odense Denmark"},{"name":"OPEN Odense Patient data Explorative Network Odense University Hospital Odense Denmark"},{"name":"Clinical Institute University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrik","family":"Fahn\u00f8e","sequence":"additional","affiliation":[{"name":"Copenhagen Hepatitis C Program (CO\u2010HEP) Department of Infectious Diseases Hvidovre Hospital and Department of Immunology and Microbiology Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin S.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Copenhagen Hepatitis C Program (CO\u2010HEP) Department of Infectious Diseases Hvidovre Hospital and Department of Immunology and Microbiology Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"},{"name":"Department of Clinical Microbiology Copenhagen University Hospital Hvidovre Hvidovre Denmark"},{"name":"Department of Clinical Microbiology Copenhagen University Hospital Rigshospitalet Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Bukh","sequence":"additional","affiliation":[{"name":"Copenhagen Hepatitis C Program (CO\u2010HEP) Department of Infectious Diseases Hvidovre Hospital and Department of Immunology and Microbiology Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"\u00d8vrehus","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Odense University Hospital Odense Denmark"},{"name":"Clinical Institute University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.02.006"},{"key":"e_1_2_12_3_1","unstructured":"WHO.https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/246177\/WHO\u2010HIV\u20102016.06\u2010eng.pdf;jsessionid=4E943B5CE4CE656E67FD2C55492C96B6?sequence=1. 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