{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:45:32Z","timestamp":1790804732109,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>HCV\u2010related extra\u2010hepatic complications include peripheral neuropathies, with important prevalence and impact. A recent metanalysis of previous intervention trials concluded for insufficient data to support evidence\u2010based treatments for this complication. In this longitudinal study, we assessed for the first time prevalence and outcome of neuropathy in a cohort of patients with chronic HCV, before and after direct\u2010acting antiviral agent (DAA) treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Ninety\u2010four patients (mean age 58.5\u00a0\u00b1\u00a09.9, infection duration 22.2\u00a0\u00b1\u00a06.3\u00a0years) without systemic and metabolic diseases, underwent neurological examination and electroneurography studies before (T0) and 10.4\u00a0\u00b1\u00a01.7\u00a0months after the end of DAA therapy (T1), and cryoglobulins (CG) assessment. Muscle strength was evaluated by Medical Research Council (MRC) score; neuropathic pain, sensory function, disability, quality of life were assessed by validated questionnaires (DN4, NPSI, SSS, INCAT and Euro\u2010QoL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At T0, sensory\u2010motor neuropathy was detected in 22 patients (23%), reflexes were depressed in 32 (34%) with no association with infection duration, viral load, age, CG. Neuropathic pain (DN4 \u22654) was present in 37 patients (39%). At T1, out of the 22 patients with altered electroneurography, 3 had died or developed HCC, 4 showed normal electroneurography, and nerve amplitude parameters tended to improve in the whole group. Only 11 patients (12%) had depressed reflexes and 10 (11%) DN4 \u22654 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05 compared to T0). Scores for MRC, questionnaires and Euro\u2010QoL improved significantly (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study confirms the high prevalence of clinical and subclinical peripheral sensory\u2010motor neuropathy in patients with HCV infection and indicates improvement after eradication by DAA. These results support the need for larger intervention studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15002","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T07:33:22Z","timestamp":1625470402000},"page":"2611-2621","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Peripheral neuropathy after viral eradication with direct\u2010acting antivirals in chronic HCV hepatitis: A prospective study"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7075-5498","authenticated-orcid":false,"given":"Maria M.","family":"Zanone","sequence":"first","affiliation":[{"name":"Internal Medicine 1 Department of Medical Sciences University of Turin Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Marinucci","sequence":"additional","affiliation":[{"name":"Internal Medicine 1 Department of Medical Sciences University 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