{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:45:38Z","timestamp":1777905938989,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CM19\/00024"],"award-info":[{"award-number":["CM19\/00024"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Sustained virological response (SVR) to direct\u2010acting antivirals ameliorates portal hypertension, improves hepatic function and may reverse the procoagulant state observed in patients with cirrhosis. However, an unexpected incidence of portal vein thrombosis (PVT) immediately after antiviral therapy has recently been reported. Therefore, we analysed the long\u2010term impact of SVR on the development of non\u2010tumoural PVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our study comprised of two well\u2010characterized prospective cohorts (hepatitis C virus \u2018(HCV)\u2010Cured\u2019: n\u00a0=\u00a0354\/\u2018HCV\u2010Active\u2019: n\u00a0=\u00a0179) of patients with HCV cirrhosis who underwent standardized ultrasound surveillance. In the main analysis, the event of interest was de novo non\u2010tumoural PVT and events known to modify its natural history (orthotopic liver transplantation, transjugular intrahepatic portosystemic shunt, death, tumoural PVT and anticoagulation) were considered as competing risk. Adjusted models were built using propensity scores for baseline covariates. Moreover, predictive factors were investigated by conventional multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten (2.8%) patients in the \u2018HCV\u2010Cured\u2019 cohort developed a non\u2010tumoural PVT during a median follow\u2010up of 37.1\u00a0months, while 8 (4.5%) patients in the \u2018HCV\u2010Active\u2019 cohort were diagnosed with non\u2010tumoural PVT during a median follow\u2010up of 42.2\u00a0months. High Child\u2010Pugh score was the only independent risk factor for non\u2010tumoural PVT development and stage A patients were at low risk. Importantly, HCV cure did not decrease the risk of non\u2010tumoural PVT in inverse probability of treatment\u2010weighted (IPTW) analysis (subdistribution hazard ratio: 1.31 (95% confidence interval [95% CI]: 0.43\u20103.97); <jats:italic>P<\/jats:italic>\u00a0=\u00a0.635). In contrast, SVR was associated with a substantial reduction in mortality (IPTW\u2010adjusted sHR: 0.453 [95% CI: 0.287\u20100.715]; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The risk of non\u2010tumoural PVT persists after HCV cure in patients with cirrhosis, despite improving survival. Even after aetiological cure, severity of liver disease remains the main determinant of non\u2010tumoural PVT development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15009","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T16:58:40Z","timestamp":1625849920000},"page":"2954-2964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Risk of non\u2010tumoural portal vein thrombosis in patients with HCV\u2010induced cirrhosis after sustained virological response"],"prefix":"10.1111","volume":"41","author":[{"given":"Mattias","family":"Mandorfer","sequence":"first","affiliation":[{"name":"Barcelona Hepatic Hemodynamic Lab Liver Unit Hospital Cl\u00ednic University of Barcelona Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Health Care Provider of the European Reference Network on Rare Liver Disorders (ERN\u2010Liver) Barcelona Spain"},{"name":"Vienna Hepatic 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