{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:43:36Z","timestamp":1790372616377,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:00:00Z","timestamp":1629936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Primary biliary cholangitis (PBC) can result in life\u2010altering cholestatic pruritus and fatigue, but treatment options are limited. Seladelpar, a peroxisome proliferator\u2010activated receptor\u2010delta (PPAR\u03b4) agonist, has demonstrated potent anti\u2010cholestatic effects in clinical studies. This open\u2010label, uncontrolled phase 2 study in PBC patients evaluated the effects of 1\u2010year of seladelpar treatment on measures of pruritus and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Self\u2010reported experiences of 101 PBC patients were collected at baseline and after 1\u00a0year of seladelpar treatment using the pruritus visual analog scale (VAS), 5D\u2010itch scale, and PBC\u201040 questionnaires along with bile acid profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In patients with moderate\u2013to\u2010severe pruritus, substantial improvement in pruritus was seen in 58% and 93% of patients in 5\/10\u00a0mg and 10\u00a0mg treatment groups, respectively. After 1\u00a0year, patients reporting improvement substantially outnumbered those who worsened in the total 5\u2010D itch (including individual domains) and PBC\u201040 (itch and fatigue domains) questionnaires. Improvement in sleep disturbance at 1\u2010year was reported in 81% (5\/10\u00a0mg) and 78% (10\u00a0mg) of the patients with baseline itch\u2010related sleep disturbance by 5\u2010D itch score with similar results using the PBC\u201040 sleep questionnaire. Seladelpar\u2010treated patients had significant reductions of 46% (5\/10\u00a0mg) and 31% (10\u00a0mg) in the serum bile acid precursor C4 and reductions of up to 38% in serum bile acids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Seladelpar treatment for 1\u00a0year led to consistent improvement in both symptom burden and biochemical response, suggesting its potential as a single agent to address two key unmet needs in PBC patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15039","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T14:28:41Z","timestamp":1629210521000},"page":"112-123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Seladelpar improved measures of pruritus, sleep, and fatigue and decreased serum bile acids in patients with primary biliary cholangitis"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9263-948X","authenticated-orcid":false,"given":"Andreas E.","family":"Kremer","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Hospital Z\u00fcrich Z\u00fcrich Switzerland"},{"name":"Department of Medicine 1 University Hospital Erlangen and Friedrich\u2010Alexander University of Erlangen\u2010N\u00fcrnberg Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlyn J.","family":"Mayo","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases University of Texas SW Medical Center Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon","family":"Hirschfield","sequence":"additional","affiliation":[{"name":"Toronto Centre for Liver Disease Toronto General Hospital University Health Network Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5498-6037","authenticated-orcid":false,"given":"Cynthia","family":"Levy","sequence":"additional","affiliation":[{"name":"Division of Digestive Health and Liver Diseases University of Miami Miller School of Medicine. Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Bowlus","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine University of California Davis Sacramento CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Jones","sequence":"additional","affiliation":[{"name":"Clinical and Translation Research Institute Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Steinberg","sequence":"additional","affiliation":[{"name":"CymaBay Therapeutics, Inc. Newark CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"McWherter","sequence":"additional","affiliation":[{"name":"CymaBay Therapeutics, Inc. 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