{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:27:28Z","timestamp":1792027648219,"version":"4.4.0"},"reference-count":150,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Obesity is a primary antecedent to non\u2010alcoholic fatty liver disease whose cardinal feature is excessive hepatic lipid accumulation. Although total hepatic lipid content closely associates with hepatic and systemic metabolic dysfunction, accumulating evidence suggests that the composition of hepatic lipids may be more discriminatory. This review summarises cross\u2010sectional human studies using liver biopsy\/lipidomics and proton magnetic resonance spectroscopy to characterise hepatic lipid composition in people with obesity and related metabolic disease. A comprehensive literature search identified 26 relevant studies published up to 31st March 2021 which were included in the review. The available evidence provides a consistent picture showing that people with hepatic steatosis possess elevated saturated and\/or monounsaturated hepatic lipids and a reduced proportion of polyunsaturated hepatic lipids. This altered hepatic lipid profile associates more directly with metabolic derangements, such as insulin resistance, and may be exacerbated in non\u2010alcoholic steatohepatitis. Further evidence from lipidomic studies suggests that these deleterious changes may be related to defects in lipid desaturation and elongation, and an augmentation of the de novo lipogenic pathway. These observations are consistent with mechanistic studies implicating saturated fatty acids and associated bioactive lipid intermediates (ceramides, lysophosphatidylcholines and diacylglycerol) in the development of hepatic lipotoxicity and wider metabolic dysfunction, whilst monounsaturated fatty acids and polyunsaturated fatty acids may exhibit a protective role. Future studies are needed to prospectively determine the relevance of hepatic lipid composition for hepatic and non\u2010hepatic morbidity and mortality; and to further evaluate the impact of therapeutic interventions such as pharmacotherapy and lifestyle interventions.<\/jats:p>","DOI":"10.1111\/liv.15059","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T19:15:11Z","timestamp":1632251711000},"page":"2819-2835","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["The role of hepatic lipid composition in obesity\u2010related metabolic disease"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8624-1427","authenticated-orcid":false,"given":"Scott A.","family":"Willis","sequence":"first","affiliation":[{"name":"National Centre for Sport and Exercise Medicine School of Sport, Exercise and Health Sciences Loughborough University Loughborough UK"},{"name":"NIHR Leicester Biomedical Research Centre University Hospitals of Leicester NHS Trust and University of Leicester Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Bawden","sequence":"additional","affiliation":[{"name":"Sir Peter Mansfield Imaging Centre University of Nottingham Nottingham UK"},{"name":"NIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and the University of Nottingham Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundus","family":"Malaikah","sequence":"additional","affiliation":[{"name":"National Centre for Sport and Exercise Medicine School of Sport, Exercise and Health Sciences Loughborough University Loughborough UK"},{"name":"NIHR Leicester Biomedical Research Centre University Hospitals of Leicester NHS Trust and University of Leicester Leicester UK"},{"name":"Faculty of Applied Medical Sciences King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0395-7329","authenticated-orcid":false,"given":"Jack A.","family":"Sargeant","sequence":"additional","affiliation":[{"name":"NIHR Leicester Biomedical Research Centre University Hospitals of Leicester NHS Trust and University of Leicester Leicester UK"},{"name":"Diabetes Research Centre University of Leicester Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Stensel","sequence":"additional","affiliation":[{"name":"National Centre for Sport and Exercise Medicine School of Sport, Exercise and Health Sciences Loughborough University Loughborough UK"},{"name":"NIHR Leicester Biomedical Research Centre University Hospitals of Leicester NHS Trust and University of Leicester Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3924-4830","authenticated-orcid":false,"given":"Guruprasad P.","family":"Aithal","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and the University of Nottingham Leicester UK"},{"name":"Nottingham Digestive Diseases Centre School of Medicine University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8174-9173","authenticated-orcid":false,"given":"James A.","family":"King","sequence":"additional","affiliation":[{"name":"National Centre for Sport and Exercise Medicine School of Sport, Exercise and Health Sciences Loughborough University Loughborough UK"},{"name":"NIHR Leicester Biomedical Research Centre University Hospitals of Leicester NHS Trust and University of Leicester Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.151"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.5888\/pcd14.160287"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1514009"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-2-200001180-00004"},{"key":"e_1_2_13_8_1","first-page":"1349","article-title":"Liver pathology in morbidly obese patients with and without diabetes","volume":"85","author":"Silverman JF","year":"1990","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29546"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.043"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.01.075"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904944106"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnz009"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.05.013"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1902"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.06.021"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1586\/egh.09.32"},{"key":"e_1_2_13_18_1","article-title":"Hepatic lipid droplets: a balancing act between energy storage and metabolic dysfunction in NAFLD","volume":"101115","author":"Mashek DG","year":"2020","journal-title":"Mol Metab"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0630588100"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.05.005"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21655"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.049478"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.06.031"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2012.10.004"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2860-6"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665118002653"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7064995"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23621"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.11.038"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.494"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.11.004"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.95"},{"key":"e_1_2_13_33_1","first-page":"1007","article-title":"Relationship between diet and non\u2010alcoholic fatty liver disease: a review article","volume":"46","author":"Mirmiran P","year":"2017","journal-title":"Iran J Public Health"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/brv.12178"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI134165"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4054-0"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0206"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328345c8c7"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108764"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2011.328"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800095-JLR200"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.06.027"},{"key":"e_1_2_13_43_1","volume-title":"The Lipid Handbook","author":"Gunstone FD","year":"1994"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21763"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313478200"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00301.2011"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2013.10.009"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.107"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-0071"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00160"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807616200"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07972.x"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-1211-9"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.126870"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29689"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-03389-2"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep44612"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.10.017"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700300R"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.06.007"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00665"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.01.002"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1318"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2013.11.013"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1113359108"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2009.10.012"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90897.2008"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154320"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2010.05.003"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29222-y"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2017.01.006"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.4.1129"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.112.171322"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)33378-7"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700394R"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2018.01.003"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3859"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46658"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22742"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v12.i8.436"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20030326"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.518"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3310-0"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27695"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2014.04.017"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/120830"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M085613"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840030215"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.03.084"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10040632"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28471"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.276.5.E977"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1622"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00064.2004"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22220"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15684-0"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1483"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4286"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a127246"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.09.009"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.2174\/157016211795569140"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14654"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092167"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-20-0401"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00063.2017"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0279"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M046607"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.127902"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.08.015"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303179"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12685"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.11.049"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1546"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2019.06.012"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2009.12.033"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31816c9013"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13451"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3766"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.134638"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0071-6"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2017.02.014"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2008.07.030"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61272-X"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2012.01.009"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31819c392e"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2011.00849.x"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.05.006"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116945"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000177812.84927.fa"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2020.100822"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2004.06.001"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12887"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-3149-9"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2007.10.002"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-015-9633-1"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2622"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2017.10.006"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.5114\/ceh.2021.106864"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.051052"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1991.tb03925.x"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012271"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092769"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo9110252"},{"key":"e_1_2_13_144_1","first-page":"402","article-title":"Differences in hepatic lipid composition linked to histological evidence of inflammation in the liver: A 1H MRS study investigating omega\u20103 fatty acid supplementation","volume":"20","author":"Stephenson MC","year":"2012","journal-title":"Proc Intl Soc Mag Reson Med"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2016.1188328"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2020.158792"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14711"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.09.008"},{"key":"e_1_2_13_149_1","first-page":"1","article-title":"PCSK9 administration ameliorates non alcoholic fatty disease in patients with heterozygous familial hyperlipidemia","volume":"9","author":"Dimakopoulou A","year":"2018","journal-title":"Hell J Atheroscler"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.04.013"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i9.1116"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.15059","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/liv.15059","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.15059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T04:10:07Z","timestamp":1692850207000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.15059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,27]]},"references-count":150,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/liv.15059"],"URL":"https:\/\/doi.org\/10.1111\/liv.15059","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,27]]},"assertion":[{"value":"2021-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}