{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T07:53:25Z","timestamp":1787298805144,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T00:00:00Z","timestamp":1636675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>The boundary between\u00a0non\u2010alcoholic (NAFLD) and alcohol\u2010related liver disease (ALD) is based on alcohol consumption. However, metabolic syndrome and alcohol use frequently co\u2010exist. The aim of this study was to determine prognostic factors of long\u2010term morbidity and mortality in patients with NAFLD or ALD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 2003 to 2016, all consecutive NAFLD or ALD patients were prospectively included in this cohort study. We evaluated overall survival, specific cause of mortality and occurrence of any complication.\u00a0The primary endpoint was analysed by the Kaplan Meier method, secondary endpoints were estimated by Gray test method or logistic regressions.\u00a0Factors independently associated with overall mortality and morbidity were identified by\u00a0a\u00a0multivariate Cox model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3365 patients (1667 with ALD and 1698 with NAFLD) were included. Median follow\u2010up was 54\u00a0months (range: 30\u201086)\u00a0and 563 subjects died.<\/jats:p><jats:p>In\u00a0the overall population, overall mortality was higher in patients with ALD (HR: 10.1 [7.57\u201013.3]), and with weekly alcohol consumption &gt;7 units (HR:1.66 [1.41\u20101.96]). Liver\u2010related mortality was higher in patients with ALD (HR: 11 [7.27\u201016.5]). In\u00a0the\u00a0NAFLD group, weekly alcohol consumption &gt;1 unit was associated with higher overall mortality (HR: 1.9 [1.1\u20103.4]), and weekly alcohol consumption &gt;7 units was associated with higher overall morbidity (OR: 1.89 [1.61\u20102.21]). In the ALD group,\u00a0the presence of metabolic syndrome was associated with higher overall (HR:1.27 [1.02\u20101.57]), and liver (HR: 1.47 [1.1\u20101.96]) mortalities, and overall (OR: 1.46 [1.14\u20101.88]), liver (OR: 1.46 [1.14\u20101.88]) morbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In fatty liver diseases, light alcohol consumption and metabolic syndrome are prognosis cofactors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15081","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T22:46:56Z","timestamp":1634942816000},"page":"350-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Long\u2010term prognosis of patients with alcohol\u2010related liver disease or non\u2010alcoholic fatty liver disease according to metabolic syndrome or alcohol use"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3304-2106","authenticated-orcid":false,"given":"Marie","family":"Decraecker","sequence":"first","affiliation":[{"name":"Hepatology unit, H\u00f4pital Haut L\u00e9v\u00eaque Bordeaux University Hospital Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Dutartre","sequence":"additional","affiliation":[{"name":"INRIA Talence France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Baptiste","family":"Hiriart","sequence":"additional","affiliation":[{"name":"Hepatology unit, H\u00f4pital Haut L\u00e9v\u00eaque Bordeaux University Hospital Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Irles\u2010Dep\u00e9","sequence":"additional","affiliation":[{"name":"Hepatology unit, H\u00f4pital Haut L\u00e9v\u00eaque Bordeaux University Hospital Bordeaux 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