{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:49:59Z","timestamp":1783536599961,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007172","name":"Cincinnati Children's Hospital Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007172","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with autoimmune hepatitis (AIH) and primary or autoimmune sclerosing cholangitis are at nutritional risk; their body composition and has not been extensively studied. We aimed to describe their body composition and identify clinical links.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using magnetic resonance imaging (MRI), two reviewers segmented total psoas muscle area (tPMSA), visceral fat area (VFA) and subcutaneous fat area (mm<jats:sup>2<\/jats:sup>) and measured visceral and subcutaneous thickness (mm). Clinical, laboratory and quality of life (QoL; using PedsQL) data were collected. Sarcopenia was defined as tPMSA \u22645th percentile. Analysis of variance, Wilcoxon rank test and multivariable modelling were performed. A paediatric cohort with non\u2010alcoholic fatty liver disease (NAFLD) was used as a comparator following propensity score matching.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010eight patients with autoimmune liver disease (AILD) (33 [57%] with AIH) were included: median age 16\u00a0years (interquartile range [IQR]: 13\u201018), 33 (57%) male. Median time from diagnosis to MRI was 15\u00a0months (IQR: 2\u201039\u00a0months). Two patients (3%) had a BMIz indicative of mild malnutrition. tPMSA was measurable in 52 subjects (90%). Of those, 25 (48%) had sarcopenia. Sarcopenic patients had a lower blood urea nitrogen compared to non\u2010sarcopenic (median [IQR]: 9.5 [8.0, 12.0] vs 11 [10, 14]\u00a0mg\/dL; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.023). There was no difference in corticosteroid use between groups. The VFA of sarcopenic patients was higher (3156 [2064, 7492]) vs 2084 [688, 3092])\u00a0mm<jats:sup>2<\/jats:sup>; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005). Patient\u2010reported QoL negatively associated with VFA and general health negatively associated with VFA. Compared with NAFLD, the odds ratio for sarcopenia with AILD was 14.5 (95% confidence interval: 2.3\u201090.7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In autoimmune liver diseases, sarcopenia is highly prevalent, associated with increased visceral fat and QoL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15108","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T09:19:54Z","timestamp":1637831994000},"page":"394-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Sarcopenia is highly prevalent in children with autoimmune liver diseases and is linked to visceral fat and parent\u2010perceived general health"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2395-5382","authenticated-orcid":false,"given":"Antoinette A.","family":"Amevor","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Cincinnati Children\u2019s Hospital Medical Center Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7260-731X","authenticated-orcid":false,"given":"Toshifumi","family":"Yodoshi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Cincinnati Children\u2019s Hospital Medical Center Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Trout","sequence":"additional","affiliation":[{"name":"Department of Radiology Cincinnati Children\u2019s Hospital Medical Center Cincinnati Ohio USA"},{"name":"Department of Radiology University of Cinncinati College of Medicine Cincinnati Ohio 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