{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T05:08:12Z","timestamp":1754111292772,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Switzerland has made strides towards hepatitis C virus elimination, but as of 2019, elimination was not guaranteed. However, political interest in viral hepatitis has been increasing. We sought to develop a better understanding of Switzerland's progress towards HCV elimination and the profile of remaining HCV\u2010RNA\u2010positive patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A previously described Markov model was updated with recent diagnosis and treatment data and run to generate new forecasts for HCV disease burden. Two scenarios were developed to evaluate HCV morbidity and mortality under the status quo and a scenario that achieves the Swiss Hepatitis Strategy Elimination targets. Next, an analysis was conducted to identify population segments bearing a high burden of disease, where future elimination efforts could be directed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the beginning of 2020, an estimated 32\u00a0100 viremic infections remained in Switzerland (0.37% viremic prevalence). Adult (\u226518\u00a0years of age) permanent residents born abroad represented the largest subpopulation, accounting for 56% of HCV infections. Thirteen countries accounted for \u226560% of viremic infections amongst permanent residents born abroad, with most people currently residing in Zurich, Vaud, Geneva, Bern, Aargau and Ticino. Amongst Swiss\u2010born HCV\u2010RNA\u2010positive persons, two\u2010thirds had a history of IDU, corresponding to 33% of total infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In Switzerland, extra efforts for diagnosis and linkage to care are warranted in foreign\u2010born populations and people with a history of drug use. Population\u2010level measures (eg increasing the number of providers, increase screening) can identify patients who may have otherwise fallen through the gaps or avoided care because of stigma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15111","type":"journal-article","created":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T06:49:06Z","timestamp":1638082146000},"page":"330-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["HCV disease burden and population segments in Switzerland"],"prefix":"10.1111","volume":"42","author":[{"given":"Florian","family":"Bihl","sequence":"first","affiliation":[{"name":"Gastroenterology and Hepatology Department Ente Ospedaliero Cantonale Bellinzona Switzerland"},{"name":"Divisions of Gastroenterology and Hepatology University Hospital Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Bruggmann","sequence":"additional","affiliation":[{"name":"Arud Centre for Addiction Medicine Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Castro Bat\u00e4njer","sequence":"additional","affiliation":[{"name":"Hepatitis C Virtual Clinic and Private Practice Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Francois","family":"Dufour","sequence":"additional","affiliation":[{"name":"University Clinic for Visceral Surgery and Medicine Inselspital University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Lavanchy","sequence":"additional","affiliation":[{"name":"Consultant Denges VD Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beat","family":"M\u00fcllhaupt","sequence":"additional","affiliation":[{"name":"Swiss HPB (Hepato\u2010Pancreato\u2010Biliary) Center and Department of Gastroenterology and Hepatology University Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4046-4806","authenticated-orcid":false,"given":"Francesco","family":"Negro","sequence":"additional","affiliation":[{"name":"Divisions of Gastroenterology and Hepatology and of Clinical Pathology University Hospital Gen\u00e8ve Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Homie","family":"Razavi","sequence":"additional","affiliation":[{"name":"CDA Foundation Lafayette Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Scheidegger","sequence":"additional","affiliation":[{"name":"Private Practice Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Semela","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Cantonal Hospital St. Gallen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasser","family":"Semmo","sequence":"additional","affiliation":[{"name":"Department for BioMedical Research, Hepatology University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9252-7576","authenticated-orcid":false,"given":"Sarah","family":"Blach","sequence":"additional","affiliation":[{"name":"CDA Foundation Lafayette Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,10]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0209374"},{"key":"e_1_2_13_3_1","unstructured":"Swiss Federal Office of Public HealthInfectious Disease Numbers Hepatitis C totally 2020.https:\/\/www.bag.admin.ch. 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