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Quantitative markers used were serum liver enzymes and FIB\u20104 score, while qualitative markers of hepatic steatosis included magnetic resonance imaging (MRI) measurements of liver fat content and total liver volume. Cox proportional hazards models, adjusted for confounding factors, were undertaken to investigate the associations of liver volume and other markers of hepatic steatosis with all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A larger MRI\u2010assessed liver volume was associated with a nearly three\u2010fold increased risk of all\u2010cause mortality (Hazard Ratio\u00a0=\u00a03.16; 95% confidence interval 1.88; 5.30), independent of age, sex, body mass index, food frequency score, alcohol consumption and education level. This association was consistent in all subgroups considered (men vs. women; presence or absence of overweight\/obesity, metabolic syndrome or diabetes). Higher serum liver enzyme levels and FIB\u20104 score were also significantly associated with higher all\u2010cause mortality in the total population and in all subgroups. No independent associations were found between other quantitative and qualitative markers of hepatic steatosis and the risk of all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We showed for the first time that larger liver volume was associated with a three\u2010fold increase in long\u2010term risk of all\u2010cause mortality. This association remained significant after adjustment for age, sex, alcohol consumption, obesity and other coexisting metabolic disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15133","type":"journal-article","created":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T09:20:07Z","timestamp":1639214407000},"page":"575-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Associations of liver volume and other markers of hepatic steatosis with all\u2010cause mortality in the general population"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8455-6599","authenticated-orcid":false,"given":"Muhammad","family":"Naeem","sequence":"first","affiliation":[{"name":"Institute for Community Medicine University Medicine Greifswald Greifswald Germany"},{"name":"Department of Zoology University of Malakand Chakdara Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello R. P.","family":"Markus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B \u2013 Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases University Medicine Greifswald Greifswald Germany"},{"name":"DZHK (German Center for Cardiovascular Research) Partner Site Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Mousa","sequence":"additional","affiliation":[{"name":"Institute for Community Medicine University Medicine Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Schipf","sequence":"additional","affiliation":[{"name":"Institute for Community Medicine University Medicine Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"D\u00f6rr","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B \u2013 Cardiology, Intensive Care, Pulmonary 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