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Integrins are heterodimeric cell\u2010surface proteins that are promising targets for therapeutic intervention. \u03b1v integrins are central in the development of fibrosis as they activate latent TGF\u03b2, a known profibrogenic cytokine. The \u03b1v subunit can form heterodimers with \u03b21, \u03b23, \u03b25, \u03b26 or \u03b28 subunits and one or more of these integrins are central to the development of liver fibrosis, however, their relative importance is not understood. 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