{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:04:05Z","timestamp":1787508245400,"version":"build-2736575974"},"reference-count":64,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T00:00:00Z","timestamp":1642896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Non\u2010alcoholic fatty liver disease (NAFLD), recently re\u2010defined and re\u2010classified as metabolic dysfunction\u2010associated fatty liver disease (MAFLD), has become increasingly prevalent and emerged as a public health problem worldwide. To date, the precise pathogenic mechanisms underpinning MAFLD are not entirely understood, and there is no effective pharmacological therapy for NAFLD\/MAFLD. As a newly discovered form of iron\u2010dependent programmed cell death, ferroptosis can be involved in the development and progression of various chronic diseases, but the pathogenic connections and mechanisms that link MAFLD and ferroptosis have not been fully elucidated. The main characteristics of ferroptosis are the accumulation of lipid peroxides and reactive oxygen species. In this brief narrative review, the mechanisms of ferroptosis and its putative pathogenic role in MAFLD are discussed to highlight potential new research directions and ideas for the prevention and treatment of MAFLD.<\/jats:p>","DOI":"10.1111\/liv.15163","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T12:49:46Z","timestamp":1641818986000},"page":"1496-1502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Ferroptosis and metabolic dysfunction\u2010associated fatty liver disease: Is there a link?"],"prefix":"10.1111","volume":"42","author":[{"given":"Gong","family":"Feng","sequence":"first","affiliation":[{"name":"Xi\u2019an Medical University  Xi\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Southampton National Institute for Health Research Biomedical Research Centre University Hospital Southampton, Southampton General Hospital  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4325-3900","authenticated-orcid":false,"given":"Giovanni","family":"Targher","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes and Metabolism, Department of Medicine University and Azienda Ospedaliera Universitaria Integrata of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8730-0003","authenticated-orcid":false,"given":"Fudi","family":"Wang","sequence":"additional","affiliation":[{"name":"The Fourth Affiliated Hospital, School of Public Health Zhejiang University School of Medicine  Hangzhou China"},{"name":"The First Affiliated Hospital, Basic Medical Sciences, School of Public Health, Hengyang Medical School University of South China  Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4984-2631","authenticated-orcid":false,"given":"Ming\u2010Hua","family":"Zheng","sequence":"additional","affiliation":[{"name":"NAFLD Research Center, Department of Hepatology the First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"},{"name":"Institute of Hepatology Wenzhou Medical University  Wenzhou China"},{"name":"Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00428-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.021"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00324-8"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.11.312"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.039"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000981"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154170"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.21037\/hbsn-21-352"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.21037\/hbsn-20-725"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00020-0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2015.02.001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.586530"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.04.001"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4770"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2016.572"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S254995"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.10.014"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.01.023"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00073-9"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.147496"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.5152\/tjg.2016.16106"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9070578"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i36.8112"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21144908"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017613"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000497228"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.11.020"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2020.102058"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29117"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.2000.9066"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04548.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084156"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071715-050939"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI44421"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1810918"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.11.048"},{"issue":"1","key":"e_1_2_9_39_1","first-page":"57","article-title":"Oxidative stress and enzymatic antioxidant status in patients with nonalcoholic steatohepatitis","volume":"34","author":"Koruk M","year":"2004","journal-title":"Ann Clin Lab Sci"},{"issue":"3","key":"e_1_2_9_40_1","first-page":"247","article-title":"MAFLD in obese children: a challenging definition","volume":"8","author":"Di Sessa A","year":"2021","journal-title":"Children (Basel)"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S302207"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-18-0054"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179889"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-3082"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30772-X"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12102954"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-018-1713-2"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12194"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2018.12.011"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.12.016"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2020-001426"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-2625"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2008.00442.x"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2019.09.011"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1678-y"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2732-5"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445269"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002907"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00253-0"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.11.030"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.06.060"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1895"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1687985"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2018.1503146"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101619"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.15163","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/liv.15163","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.15163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:05:52Z","timestamp":1699229152000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.15163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,23]]},"references-count":64,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/liv.15163"],"URL":"https:\/\/doi.org\/10.1111\/liv.15163","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,23]]},"assertion":[{"value":"2021-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}