{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:38:43Z","timestamp":1785267523425,"version":"3.55.0"},"reference-count":102,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Non\u2010selective beta\u2010blockers (NSBBs) are the cornerstone of the primary and secondary prophylaxis of variceal bleeding in cirrhotic patients. They additionally prevent ascites development and death in compensated patients with clinically significant portal hypertension. After ascites onset, NSBBs remain beneficial for preventing further decompensations. However, as the cirrhosis progresses, the inflammation increases, systemic vasodilatation worsens, ascites turns refractory and cardiodynamic equilibrium becomes extremely fragile. In this scenario, NSBBs can critically impair the cardiac reserve and facilitate a haemodynamic breakdown, imperilling renal perfusion. Consequently, NSBB treatment should be carefully monitored or even avoided in such patients, and other options for portal hypertension management should be considered. In the present review, we explore the effects of NSBBs in patients with ascites and discuss the complex interplay among their hepatic, systemic and renal haemodynamic effects in this scenario.<\/jats:p>","DOI":"10.1111\/liv.15166","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T17:08:58Z","timestamp":1642698538000},"page":"749-761","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Non\u2010selective beta\u2010blockers in patients with ascites: The\u00a0complex interplay among the liver, kidney and heart"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9254-3891","authenticated-orcid":false,"given":"Luis","family":"T\u00e9llez","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), Hospital Universitario Ram\u00f3n y Cajal Universidad de Alcal\u00e1  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"Albillos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), Hospital Universitario Ram\u00f3n y Cajal Universidad de Alcal\u00e1  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198112033052302"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)93125-s"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199105303242202"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007133"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3282748f07"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004544.pub2"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12396"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011510.pub2"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30220"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v11.i5.464"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.20524\/aog.2019.0368"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.1997.v25.pm0008985266"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i47.5982"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05074.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29267"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.456"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12452"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31875-0"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2009.02038.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)91168-6"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00453.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.05.050"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23775"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301348"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20766"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.180570"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.048"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.10.002"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.05.011"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29104"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.01.006"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13065"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.01.003"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.10.004"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.00790.x"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0901512"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.36947"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300124"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-304038"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044456"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28264"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.03.048"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50133"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322712"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.10.018"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13890"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12782"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22853"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.10.020"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.01.022"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001990"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16189"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.02.005"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.024"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.12.022"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.07.002"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.07.004"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21945"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.191"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28352"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90441-6"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15439"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13119"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(96)70068-9"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.01.034"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4098210"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28575"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24744"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.03.005"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.01.031"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14366"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2015.11.018"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13409"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312129"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.01.012"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5092-6"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14040"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840020518"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.12.027"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655201750313289"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.11.003"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep0498"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13870"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22533"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(97)80259-0"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.3.H1299"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1990.258.2.F364"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.10.055"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs205"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12528"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.09.032"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.09.016"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2016.02.041"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1642"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.10.003"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.10.023"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24053"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306502"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26676"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.948053"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2017.1329456"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28906"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.15166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/liv.15166","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.15166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T12:56:44Z","timestamp":1693141004000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.15166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,11]]},"references-count":102,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/liv.15166"],"URL":"https:\/\/doi.org\/10.1111\/liv.15166","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,11]]},"assertion":[{"value":"2021-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}