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Adverse events (AEs) were collected by questionnaire. The antibody profiles at 1, 2 and 3\u00a0months were elucidated by determination of anti\u2010spike IgG, anti\u2010receptor\u2010binding domain (RBD) IgG, and RBD\u2010angiotensin\u2010converting enzyme 2 blocking antibody. SARS\u2010CoV\u20102 specific B cells were also analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All AEs were mild and self\u2010limiting, and the incidence was similar between CHB patients and controls. Seropositivity rates of three antibodies were similar between CHB patients and healthy controls at 1, 2 and 3\u00a0months, but CHB patients had lower titers of three antibodies at 1\u00a0month. Compared to healthy controls, HBeAg\u2010positive CHB patients had higher titers of three antibodies at 3\u00a0months (all P\u00a0&lt;\u00a0.05) and a slower decline in antibody titers. Frequency of RBD\u2010specific B cells was positively correlated with titers of anti\u2010RBD IgG (OR\u00a0=\u00a01.067, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004), while liver cirrhosis, antiviral treatment, levels of HBV DNA, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and total bilirubin (TB) were not correlated with titers of anti\u2010RBD IgG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Inactivated COVID\u201019 vaccines were well tolerated, and induced effective antibody response against SARS\u2010CoV\u20102 in CHB patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15173","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T13:30:14Z","timestamp":1643808614000},"page":"1287-1296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Safety and antibody response to inactivated COVID\u201019 vaccine in patients with chronic hepatitis B virus infection"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4420-6364","authenticated-orcid":false,"given":"Taiyu","family":"He","sequence":"first","affiliation":[{"name":"Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology for 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