{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:53:28Z","timestamp":1780451608507,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100016148","name":"Korean Liver Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016148","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016147","name":"Korean Association for the Study of the Liver","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016147","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>As most staging systems for intrahepatic cholangiocarcinoma (iCCA) are based on pathological results, preoperative prognostic prediction is limited. This study aimed to develop and validate a prognostic model for the overall survival of patients with mass\u2010forming iCCA (MF\u2010iCCA) using preoperative magnetic resonance imaging (MRI) and clinical findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled a total of 316 patients who underwent preoperative MRI and surgical resection for treatment\u2010naive MF\u2010iCCA from six institutions, between January 2009 and December 2015. The subjects were randomly assigned to a training set (<jats:italic>n<\/jats:italic>\u00a0=\u00a0208) or validation set (<jats:italic>n<\/jats:italic>\u00a0=\u00a0108). The MRIs were independently reviewed by three abdominal radiologists. Using MRI and clinical findings, an MRI prognostic score was established. We compared the discrimination performance of MRI prognostic scores with those of conventional pathological staging systems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We developed an MRI prognostic score consisting of serum CA19\u20109 and three MRI findings (tumour multiplicity, lymph node metastasis and bile duct invasion). The MRI prognostic score demonstrated good discrimination performance in both the training set (C\u2010index, 0.738; 95% confidence interval [CI], 0.698\u20130.780) and validation set (C\u2010index, 0.605; 95% CI, 0.526\u20130.680). In the validation set, MRI prognostic score showed no significant difference with AJCC 8th TNM stage, MEGNA score and Nathan\u2019s stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our MRI prognostic score for overall survival of MF\u2010iCCA showed comparable discriminatory performance with pathological staging systems and might be used to determine an optimal treatment strategy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15196","type":"journal-article","created":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T08:53:49Z","timestamp":1644742429000},"page":"930-941","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Preoperative magnetic resonance imaging\u2010based prognostic model for mass\u2010forming intrahepatic cholangiocarcinoma"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7759-4458","authenticated-orcid":false,"given":"Hyungjin","family":"Rhee","sequence":"first","affiliation":[{"name":"Department of Radiology Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6898-6617","authenticated-orcid":false,"given":"Sang Hyun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology University of Ulsan College of Medicine, Asan Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6794-4909","authenticated-orcid":false,"given":"Ji Hoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiology Seoul National University Bundang Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun\u2010Suk","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Radiology Gangnam Severance Hospital, Yonsei University College of Medicine Seoul  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3390-9793","authenticated-orcid":false,"given":"Suk\u2010Keu","family":"Yeom","sequence":"additional","affiliation":[{"name":"Department of Radiology Korea University Ansan Hospital, Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumi","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiology National Health Insurance Service Ilsan Hospital  Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5687-7237","authenticated-orcid":false,"given":"Kyunghwa","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Radiology Research Institute of Radiological Science, Center for Clinical Imaging Data Science, College of Medicine, Yonsei University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5518-2249","authenticated-orcid":false,"given":"Seung Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology University of Ulsan College of Medicine, Asan Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5817-2444","authenticated-orcid":false,"given":"Mi\u2010Suk","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiology 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