{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:22:00Z","timestamp":1790914920927,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["EC11\u20100489"],"award-info":[{"award-number":["EC11\u20100489"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["MV and MS are recipient of the Juan Rod\u00e9s grant"],"award-info":[{"award-number":["MV and MS are recipient of the Juan Rod\u00e9s grant"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["INTEAM Funding Source"],"award-info":[{"award-number":["INTEAM Funding Source"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U01AA021908"],"award-info":[{"award-number":["U01AA021908"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["center P30 DK120515"],"award-info":[{"award-number":["center P30 DK120515"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Alcoholic hepatitis (AH) is associated with a high incidence of infection and mortality. Rifaximin reduces bacterial overgrowth and translocation. We aimed to study whether the administration of rifaximin as an adjuvant treatment to corticosteroids decreases the number of bacterial infections at 90\u00a0days in patients with severe AH compared to a control cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a multicentre, open, comparative pilot study of the addition of rifaximin (1200\u00a0mg\/day\/90\u00a0days) to the standard treatment for severe AH. The results were compared with a carefully matched historical cohort of patients treated with standard therapy and matching by age and model of end\u2010stage liver disease (MELD). We evaluated bacterial infections, liver\u2010related complications, mortality and liver function tests after 90\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010one and 42 patients were included in the rifaximin and control groups respectively. No significant baseline differences were found between groups. The mean number of infections per patient was 0.29 and 0.62 in the rifaximin and control groups, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.049), with a lower incidence of acute\u2010on\u2010chronic liver failure (ACLF) linked to infections within the treatment group. Liver\u2010related complications were lower within the rifaximin group (0.43 vs. 1.26 complications\/patient respectively) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.01). Mortality was lower in the treated versus the control groups (14.2% vs. 30.9, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.15) without significant differences. No serious adverse events were associated with rifaximin treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Rifaximin is safe in severe AH with a significant reduction in clinical complications. A lower number of infections and a trend towards a lower ACLF and mortality favours its use in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15207","type":"journal-article","created":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T03:03:49Z","timestamp":1645931029000},"page":"1109-1120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Effect of rifaximin on infections, acute\u2010on\u2010chronic liver failure and mortality in alcoholic hepatitis: A pilot study (RIFA\u2010AH)"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2455-2048","authenticated-orcid":false,"given":"C\u00e9sar","family":"Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Vall d'Hebron Hospital Universitari, Liver Unit; Vall d'Hebron Institut de Recerca, Liver Unit Universitat Autonoma de Barcelona, Department of Medicine  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9513-2855","authenticated-orcid":false,"given":"Meritxell","family":"Ventura\u2010Cots","sequence":"additional","affiliation":[{"name":"Vall d'Hebron Hospital Universitari, Liver Unit; Vall d'Hebron Institut de Recerca, Liver Unit Universitat Autonoma de Barcelona, Department of Medicine  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Madrid Spain"},{"name":"Center for Liver Diseases, Pittsburgh Liver Research Center, Division of Gastroenterology Hepatology and Nutrition, University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4879-1780","authenticated-orcid":false,"given":"Margarita","family":"Sala","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Madrid Spain"},{"name":"Gastroenterology Department Hospital Universitari Germans Trias I Pujol  Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2335-3792","authenticated-orcid":false,"given":"Margalida","family":"Calafat","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd)  Madrid Spain"},{"name":"Gastroenterology Department Hospital Universitari Germans Trias I Pujol  Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6783-7604","authenticated-orcid":false,"given":"Montserrat","family":"Garcia\u2010Retortillo","sequence":"additional","affiliation":[{"name":"Liver Section, Gastroenterology Department, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute) Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8342-6474","authenticated-orcid":false,"given":"Isabel","family":"Cirera","sequence":"additional","affiliation":[{"name":"Liver Section, Gastroenterology Department, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute) Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9501-7590","authenticated-orcid":false,"given":"Nuria","family":"Ca\u00f1ete","sequence":"additional","affiliation":[{"name":"Liver Section, Gastroenterology Department, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute) Universitat Aut\u00f2noma de Barcelona  Barcelona 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