{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:28:58Z","timestamp":1754486938926,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>limited evidence is available to guide hepatologists regarding endoscopic surveillance of oesophageal varices (EV) in Hepatitis C Virus (HCV)\u2010positive cirrhotic patients achieving a sustained virologic response. To address these issues, we conducted a long\u2010term prospective study on 427 HCV\u2010positive cirrhotic patients successfully treated by Direct Antiviral Agents (DAAs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were divided into two groups according to their baseline Baveno VI status: Group 1 (92, 21.5%, favourable Baveno VI status) and Group 2 (335, 78.5%, unfavourable Baveno VI status). Each patient underwent baseline endoscopy and was endoscopically monitored for a median follow\u2010up of 65.2\u00a0months according to Baveno VI recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>About 4.3% of Group 1 patients showed baseline EV compared with 30.1% of Group 2 patients (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001). No patients belonging to Group 1 without baseline EV developed EV at follow\u2010up endoscopy compared with 6.5% in Group 2 patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.02); 69\/107 (64.5%) patients with baseline EV showed small varices. During the endoscopic follow\u2010up, EV disappeared\/improved in 36 (33.6%), were stable in 39 (36.4%) and worsened in 32 (29.9%) patients, all belonging to Group 2 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.001). Improvement in Baveno VI status was observed in 118\/335 (35.2%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001) of Group 2 patients and among those without pre\u2010therapy EV, none developed EV throughout the follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HCV\u2010positive cirrhotic patients cured by DAAs showing baseline favourable Baveno VI status and no worsening during follow\u2010up can safely avoid endoscopic screening and surveillance. Patients having unfavourable Baveno VI status without baseline EV who improve their status may suspend further endoscopic surveillance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15210","type":"journal-article","created":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T04:43:45Z","timestamp":1645937025000},"page":"1121-1131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Screening and surveillance of oesophageal varices in patients with HCV\u2010positive liver cirrhosis successfully treated by direct\u2010acting antiviral agents"],"prefix":"10.1111","volume":"42","author":[{"given":"Alessia","family":"Ciancio","sequence":"first","affiliation":[{"name":"Gastro\u2010hepatoloy Unit, Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9421-3087","authenticated-orcid":false,"given":"Davide 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