{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T13:09:12Z","timestamp":1782306552387,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Herpes simplex virus 1 (HSV\u20101) is a frequently unrecognized, yet deadly cause of acute liver failure (ALF). We, therefore, analysed three cases of fatal HSV\u20101\u2010induced ALF. All patients shared clinical (extremely elevated transaminases, LDH and AST\/LDH ratio\u00a0&lt;\u00a01) and virological characteristics (ratio of viral load in plasma versus throat swabs: 60\u2013700\u2010fold, lack of anti\u2010HSV\u20101\u2010IgG antibodies or low IgG\u2010avidity during primary infection), which may help to identify patients at risk. Additionally, in vitro chemosusceptibility assays revealed high efficacy of the helicase\u2010primase inhibitors (HPI), pritelivir and drug\u2010candidate IM\u2010250 compared to acyclovir (ACV) using HSV\u20101\u2010isolates from two patients; hence, ACV\/HPI\u2010combinations might offer new therapeutic options for HSV\u2010induced ALF.<\/jats:p>","DOI":"10.1111\/liv.15215","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T15:30:28Z","timestamp":1646148628000},"page":"1005-1011","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comprehensive clinical and virological characterization of three cases of fulminant liver failure owing to <scp>HSV1<\/scp> primary infection"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2807-5955","authenticated-orcid":false,"given":"Stephan","family":"Spahn","sequence":"first","affiliation":[{"name":"Department Internal Medicine I University Hospital of Tuebingen  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reimer","family":"Riessen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical Intensive Care Unit University Hospital of Tuebingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7318-9268","authenticated-orcid":false,"given":"Christoph P.","family":"Berg","sequence":"additional","affiliation":[{"name":"Department Internal Medicine I University Hospital of Tuebingen  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisar P.","family":"Malek","sequence":"additional","affiliation":[{"name":"Department Internal Medicine I University Hospital of Tuebingen  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzena 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