{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:35:29Z","timestamp":1792712129211,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T00:00:00Z","timestamp":1647043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015669","name":"European Society for Photobiology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Diagnostic histological criteria for autoimmune hepatitis (AIH) have not been clearly established. Previously published criteria focused mainly on chronic AIH, in which inflammatory changes mainly occur in portal\/periportal regions and may not be applicable to acute presentation of AIH, in which inflammatory changes are typically predominantly lobular in location. International consensus criteria for the diagnosis and assessment of disease severity in both acute and chronic AIH are thus urgently needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seventeen expert liver pathologists convened at an international workshop and subsequently used a modified Delphi panel approach to establish consensus criteria for the histopathological diagnosis of AIH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The consensus view is that liver biopsy should remain standard for diagnosing AIH. AIH is considered likely, if there is a predominantly portal lymphoplasmacytic hepatitis with more than mild interface activity and\/or more than mild lobular hepatitis in the absence of histological features suggestive of another liver disease. AIH is also considered likely if there is predominantly lobular hepatitis with or without centrilobular necroinflammation and at least one of the following features: portal lymphoplasmacytic hepatitis, interface hepatitis or portal\u2010based fibrosis, in the absence of histological features suggestive of another liver disease. Emperipolesis and hepatocellular rosettes are not regarded as being specific for AIH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The criteria proposed in this consensus statement provide a uniform approach to the histological diagnosis of AIH, which is relevant for patients with an acute as well as a chronic presentation and to more accurately reflect the current understanding of liver pathology in AIH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15217","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T10:30:27Z","timestamp":1646130627000},"page":"1058-1069","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":151,"title":["Consensus recommendations for histological criteria of autoimmune hepatitis from the International\n                    <scp>AIH<\/scp>\n                    Pathology Group"],"prefix":"10.1111","volume":"42","author":[{"given":"Ansgar W.","family":"Lohse","sequence":"first","affiliation":[{"name":"Department of Medicine University Medical Centre Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"European Reference Network on Hepatological Diseases (ERN RARE\u2010LIVER)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5163-6979","authenticated-orcid":false,"given":"Marcial","family":"Sebode","sequence":"additional","affiliation":[{"name":"Department of Medicine University Medical Centre Hamburg\u2010Eppendorf  Hamburg Germany"},{"name":"European Reference Network on Hepatological Diseases (ERN RARE\u2010LIVER)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prithi S.","family":"Bhathal","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Clouston","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Pathology The University of Queensland and Envoi Specialist Pathologists  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans P.","family":"Dienes","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhanpat","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette S. H.","family":"Gouw","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Guindi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Kakar","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3442-4453","authenticated-orcid":false,"given":"David E.","family":"Kleiner","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology National Cancer Institute, National Institutes of Health  Bethesda Maryland 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