{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:29:55Z","timestamp":1792189795004,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>The high risk for severe shunting\u2010related post\u2010interventional complications demands a stringent selection of candidates for transjugular intrahepatic portosystemic shunt (TIPS). We aimed to develop a simple and reliable tool to accurately predict early post\u2010TIPS mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      144 cases of TIPS implantation were retrospectively analysed. Using univariate and multivariate Cox regression analysis of factors predicting mortality within 90\u00a0days after TIPS, a score integrating urea, international normalized ratio (INR) and bilirubin was developed. The Modified TIPS\u2010Score (MOTS) ranges from 0 to 3 points: INR &gt;1.6, urea &gt;71\u00a0mg\/dl and bilirubin &gt;2.2\u00a0mg\/dl account for one point each. Additionally, MOTS was tested in an external validation cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0187) and its performance was compared to existing models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Modified TIPS\u2010Score achieved a significant prognostic discrimination reflected by 90\u2010day mortality of 8% in patients with MOTS 0\u20131 and 60% in patients with MOTS 2\u20133 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Predictive performance (area under the curve) of MOTS was accurate (\n                      <jats:italic>c<\/jats:italic>\n                      \u00a0=\u00a00.845 [0.73\u20130.96],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), also in patients with renal insufficiency (\n                      <jats:italic>c<\/jats:italic>\n                      \u00a0=\u00a00.830 [0.64\u20131.00],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.02) and in patients with refractory ascites (\n                      <jats:italic>c<\/jats:italic>\n                      \u00a0=\u00a00.949 [0.88\u20131.00],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), which are subgroups with particular room for improvement of post\u2010TIPS mortality prediction. The results were reproducible in the validation cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Modified TIPS\u2010Score is a novel, practicable tool to predict post\u2010TIPS mortality, that can significantly simplify clinical decision making. Its practical applicability should be further investigated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15236","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T03:10:09Z","timestamp":1646795409000},"page":"1849-1860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A novel score predicts mortality after transjugular intrahepatic portosystemic shunt: MOTS \u2010 Modified TIPS Score"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9704-862X","authenticated-orcid":false,"given":"Luisa","family":"F\u00fcrschu\u00df","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Research Unit \u201cTransplantation Research\u201d Medical University of Graz  Graz 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