{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T17:41:45Z","timestamp":1783618905573,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>The coronavirus disease of 2019 (COVID\u201019) causes considerable mortality worldwide. We aimed to investigate the frequency and predictive role of abnormal liver chemistries in different age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with positive severe acute respiratory distress syndrome\u2010coronavirus\u20102 (SARS\u2010CoV\u20102) polymerase chain reaction (PCR) test between 03\/2020\u201007\/2021 at the Vienna General Hospital were included. Patients were stratified for age: 18\u201339 vs. 40\u201369 vs. \u226570\u2009years (y). Aspartate aminotransferase (AST), alanine\u2010aminotransferase (ALT), alkaline phosphatase (ALP), gamma\u2010glutamyl transferase (GGT) and total bilirubin (BIL) were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>900 patients (18\u201339\u2009years: 32.2%, 40\u201369\u2009years: 39.7%, \u226570\u2009years: 28.1%) were included. Number of comorbidities, median D\u2010dimer and C\u2010reactive protein increased with age. During COVID\u201019, AST\/ALT and ALP\/GGT levels significantly increased. Elevated hepatocellular transaminases (AST\/ALT) and cholestasis parameters (ALP\/GGT\/BIL) were observed in 40.3% (<jats:italic>n<\/jats:italic> \u00a0=\u00a0262\/650) and 45.0% (<jats:italic>n<\/jats:italic> \u00a0=\u00a0287\/638) of patients respectively. Liver\u2010related mortality was highest among patients with pre\u2010existing decompensated liver disease (28.6%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). 1.7% of patients without pre\u2010existing liver disease died of liver\u2010related causes, that is consequences of hepatic dysfunction or acute liver failure. Importantly, COVID\u201019\u2010associated liver injury (16.0%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), abnormal liver chemistries and liver\u2010related mortality (6.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) were most frequent among 40\u201369\u2009years old patients. Elevated AST and BIL after the first positive SARS\u2010CoV\u20102 PCR independently predicted mortality in the overall cohort and in 40\u201369\u2009years old patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Almost half of the COVID\u201019 patients exhibit abnormal hepatocellular and cholestasis\u2010related liver chemistries with 40\u201369\u2009years old patients being at particularly high risk for COVID\u201019\u2010related liver injury and liver\u2010related mortality. Elevated AST and BIL after SARS\u2010CoV\u20102 infection are independent predictors of mortality, especially in patients aged 40\u201369\u2009years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15274","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T11:14:09Z","timestamp":1649762049000},"page":"1297-1307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Age\u2010adjusted mortality and predictive value of liver chemistries in a Viennese cohort of <scp>COVID<\/scp>\u201019 patients"],"prefix":"10.1111","volume":"42","author":[{"given":"Lukas","family":"Hartl","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Lab, Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Haslinger","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Lab, Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Angerer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Lab, Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Jachs","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Lab, Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8181-9146","authenticated-orcid":false,"given":"Benedikt","family":"Simbrunner","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Lab, Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna Austria"},{"name":"Christian Doppler Lab for Portal Hypertension and Liver Fibrosis Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9363-8518","authenticated-orcid":false,"given":"David J. M.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Lab, Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0411-166X","authenticated-orcid":false,"given":"Georg","family":"Semmler","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna Austria"},{"name":"Vienna Hepatic Hemodynamic Lab, Division of Gastroenterology and Hepatology, Department of Medicine III Medical University of Vienna  Vienna 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