{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:15:30Z","timestamp":1790673330860,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Evidence for the benefit of scheduled imaging for early detection of hepatobiliary malignancies in primary sclerosing cholangitis (PSC) is limited. We aimed to compare different follow\u2010up strategies in PSC with the hypothesis that regular imaging improves survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We collected retrospective data from 2975 PSC patients from 27 centres. Patients were followed from the start of scheduled imaging or in case of clinical follow\u2010up from 1 January 2000, until death or last clinical follow\u2010up alive. The primary endpoint was all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A broad variety of different follow\u2010up strategies were reported. All except one centre used regular imaging, ultrasound (US) and\/or magnetic resonance imaging (MRI). Two centres used scheduled endoscopic retrograde cholangiopancreatography (ERCP) in addition to imaging for surveillance purposes. The overall HR (CI95%) for death, adjusted for sex, age and start year of follow\u2010up, was 0.61 (0.47\u20130.80) for scheduled imaging with and without ERCP; 0.64 (0.48\u20130.86) for US\/MRI and 0.53 (0.37\u20130.75) for follow\u2010up strategies including scheduled ERCP. The lower risk of death remained for scheduled imaging with and without ERCP after adjustment for cholangiocarcinoma (CCA) or high\u2010grade dysplasia as a time\u2010dependent covariate, HR 0.57 (0.44\u20130.75). Hepatobiliary malignancy was diagnosed in 175 (5.9%) of the patients at 7.9\u2009years of follow\u2010up. Asymptomatic patients (25%) with CCA had better survival if scheduled imaging had been performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Follow\u2010up strategies vary considerably across centres. Scheduled imaging was associated with improved survival. Multiple factors may contribute to this result including early tumour detection and increased endoscopic treatment of asymptomatic benign biliary strictures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15286","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T05:25:37Z","timestamp":1652160337000},"page":"127-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Impact on follow\u2010up strategies in patients with primary sclerosing cholangitis"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3858-6241","authenticated-orcid":false,"given":"Annika","family":"Bergquist","sequence":"first","affiliation":[{"name":"Department of Medicine Huddinge, Unit of Gastroenterology and Rheumatology Karolinska Institutet, Karolinska University Hospital  Stockholm Sweden"},{"name":"European Reference Network for Hepatological Diseases  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9736-1483","authenticated-orcid":false,"given":"Tobias J.","family":"Weism\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Hospital Bonn, University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5498-6037","authenticated-orcid":false,"given":"Cynthia","family":"Levy","sequence":"additional","affiliation":[{"name":"Division of Digestive Health and Liver Diseases University of Miami  Florida USA"},{"name":"Schiff Center for Liver Diseases University of Miami  Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Rupp","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Infectious Diseases, Intoxication Heidelberg University Hospital  Heidelberg 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