{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:48:56Z","timestamp":1781074136125,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While ALPPS triggers a fast liver hypertrophy, it is still unclear which factors matter most to achieve accelerated hypertrophy within a short period of time. The aim of the study was to identify patient\u2010intrinsic factors related to the growth of the future liver remnant (FLR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cohort study is composed of data derived from the International ALPPS Registry from November 2011 and October 2018. We analyse the influence of demographic, tumour type and perioperative data on the growth of the FLR. The volume of the FLR was calculated in millilitre and percentage using computed\u2010tomography (CT) scans before and after stage 1, both according to Vauthey formula.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 734 patients were included from 99 centres. The median sFLR at stage 1 and stage 2 was 0.23 (IQR, 0.18\u20130.28) and 0.39 (IQR: 0.31\u20130.46), respectively. The variables associated with a lower increase from sFLR1 to sFLR2 were age\u02c368\u2009years (p =\u2009.02), height \u02c31.76\u2009m (p \u02c2 .01), weight \u02c383\u2009kg (p \u02c2 .01), BMI\u02c328 (p \u02c2 .01), male gender (p \u02c2 .01), antihypertensive therapy (p \u02c2 .01), operation time \u02c3370\u2009minutes (p \u02c2 .01) and hospital stay\u02c314\u2009days (p \u02c2 .01). The time required to reach sufficient volume for stage 2, male gender accounts 40.3% in group \u02c27\u2009days, compared with 50% of female, and female present 15.3% in group \u02c314\u2009days compared with 20.6% of male.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Height, weight, FLR size and gender could be the variables that most constantly influence both daily growths, the interstage increase and the standardized FLR before the second stage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15287","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T15:55:16Z","timestamp":1652111716000},"page":"2815-2829","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Liver growth prediction in <scp>ALPPS<\/scp> \u2013 A multicenter analysis from the international <scp>ALPPS<\/scp> registry"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1718-3352","authenticated-orcid":false,"given":"Victor","family":"Lopez\u2010Lopez","sequence":"first","affiliation":[{"name":"Virgen de la Arrixaca Clinic and University Hospital Departament of Surgery and Transplantation IMIB\u2010Arrixaca  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Linecker","sequence":"additional","affiliation":[{"name":"Department of Surgery and Transplantation University Medical Center Schleswig\u2010Holstein  Campus Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Cruz","sequence":"additional","affiliation":[{"name":"Group of Applied Mathematics in Science and Engineering, Faculty of Computer Science University of Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Brusadin","sequence":"additional","affiliation":[{"name":"Virgen de la Arrixaca Clinic and University Hospital Departament of Surgery and Transplantation IMIB\u2010Arrixaca  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuncion","family":"Lopez\u2010Conesa","sequence":"additional","affiliation":[{"name":"Virgen de la Arrixaca Clinic and University Hospital Departament of Surgery and Transplantation IMIB\u2010Arrixaca  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel Autran","family":"Machado","sequence":"additional","affiliation":[{"name":"Department of Surgery Hospital Adventista Silvestre  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Hernandez\u2010Alejandro","sequence":"additional","affiliation":[{"name":"Division of Transplantation\/Hepatobiliary Surgery, Department of Surgery University of Rochester  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro Sergey","family":"Voskanyan","sequence":"additional","affiliation":[{"name":"Department of Surgery A.I. Burnazyan FMBC Russian State Scientific Center of FMBA  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Balci","sequence":"additional","affiliation":[{"name":"Department of Surgery Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Adam","sequence":"additional","affiliation":[{"name":"Centre H\u00e9pato\u2010Biliaire H\u00f4pital Paul Brousse  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Ardiles","sequence":"additional","affiliation":[{"name":"Liver Transplant Unit, Division of HPB Surgery, Department of Surgery Italian Hospital Buenos Aires  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