{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T20:38:03Z","timestamp":1779223083281,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>In other forms of chronic liver disease, measurement of portal pressure is of prognostic value, but this has not yet been established in primary biliary cholangitis (PBC). The aim of the study is to determine the prognostic value of hepatic venous pressure gradient (HVPG) in relation to liver\u2010related survival outcomes, as well as to the development of hepatic decompensation, oesophageal varices and variceal bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Baseline HVPG and liver biopsies were obtained in 86 patients followed for 10\u2009years in a controlled trial of colchicine treatment, and subsequently in a long\u2010term observational cohort study for a further 30\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 49 Hepatic deaths in addition to 10 Liver Transplants (Hepatic death\/transplant;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a059). Some of these were associated with a significant variceal bleed within 3\u00a0months of death or transplant (Portal hypertension\u2010associated death or transplant;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a019). There were 63 deaths from all causes. During follow\u2010up, oesophageal varices developed in 26 patients, whilst 17 bled from varices and 32 developed hepatic decompensation over a median follow\u2010up of 18.1\u2009years (1.9\u201328.5). Baseline HVPG was highly predictive of all 6 clinical outcomes and contributed significant predictive information additional to that provided by Mayo score and Ludwig stage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Measurement of baseline portal pressure is of significant prognostic value in primary biliary cholangitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15289","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T12:18:30Z","timestamp":1653653910000},"page":"139-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Portal pressure is of significant prognostic value in primary biliary cholangitis"],"prefix":"10.1111","volume":"43","author":[{"given":"Thomas W.","family":"Warnes","sequence":"first","affiliation":[{"name":"Liver Unit, Department of Gastroenterology Manchester Royal Infirmary  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen A.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Division of Population Health Health Services Research and Primary Care, University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Smith","sequence":"additional","affiliation":[{"name":"Liver Unit, Department of Gastroenterology Manchester Royal Infirmary  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor M.","family":"Cope","sequence":"additional","affiliation":[{"name":"Department of Radiology Manchester Royal Infirmary  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Vales","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Manchester Royal Infirmary  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8921-3330","authenticated-orcid":false,"given":"Raymond","family":"McMahon","sequence":"additional","affiliation":[{"name":"Department of Histopathology Manchester Royal Infirmary  Manchester 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