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This study characterizes the outcomes and mortality risk in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multicentre retrospective, cross\u2010sectional, international study of liver cancer patients with SARS\u2010CoV\u20102 infection registered between February and December 2020. Clinical data at SARS\u2010CoV\u20102 diagnosis and outcomes were registered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two hundred fifty patients from 38 centres were included, 218 with hepatocellular carcinoma (HCC) and 32 with intrahepatic cholangiocarcinoma (iCCA). The median age was 66.5 and 64.5\u2009years, and 84.9% and 21.9% had cirrhosis in the HCC and iCCA cohorts respectively. Patients had advanced cancer stage at SARS\u2010CoV\u20102 diagnosis in 39.0% of the HCC and 71.9% of the iCCA patients. After a median follow\u2010up of 7.20 (IQR: 1.84\u201311.24) months, 100 (40%) patients have died, 48% of the deaths were SARS\u2010CoV\u20102\u2010related. Forty (18.4%) HCC patients died within 30\u2010days. The death rate increase was significantly different according to the BCLC stage (6.10% [95% CI 2.24\u201312.74], 11.76% [95% CI 4.73\u201322.30], 20.69% [95% CI 11.35\u201331.96] and 34.52% [95% CI 17.03\u201352.78] for BCLC 0\/A, B, C and D, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0017). The hazard ratio was 1.45 (95% CI 0.49\u20134.31;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.5032) in BCLC\u2010B versus 0\/A, and 3.13 (95% CI 1.29\u20137.62;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0118) in BCLC\u2010C versus 0\/A in the competing risk Cox regression model. Nineteen out of 32 iCCA (59.4%) died, and 12 deaths were related to SARS\u2010CoV\u20102 infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the largest cohort of liver cancer patients infected with SARS\u2010CoV\u20102. It characterizes the 30\u2010day mortality risk of SARS\u2010CoV\u20102 infected patients with HCC during this period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15320","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T12:19:21Z","timestamp":1653394761000},"page":"1891-1901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Outcome of liver cancer patients with SARS\u2010CoV\u20102 infection: An International, Multicentre, Cohort Study"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0663-0575","authenticated-orcid":false,"given":"Sergio","family":"Mu\u00f1oz\u2010Mart\u00ednez","sequence":"first","affiliation":[{"name":"Unitat d'Oncologia hep\u00e0tica, Liver Unit, Hospital Cl\u00ednic  Barcelona Spain"},{"name":"BCLC group, IDIBAPS  Barcelona Spain"},{"name":"CIBEREHD  Barcelona Spain"},{"name":"Universitat de Barcelona (UB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4379-6486","authenticated-orcid":false,"given":"Victor","family":"Sapena","sequence":"additional","affiliation":[{"name":"Unitat d'Oncologia hep\u00e0tica, Liver Unit, Hospital Cl\u00ednic  Barcelona Spain"},{"name":"BCLC group, IDIBAPS  Barcelona Spain"},{"name":"Universitat de Barcelona (UB)  Barcelona Spain"},{"name":"Medical Statistics Core Facility, Institut D'Investigacions Biom\u00e9diques August Pi i Sunyer (IDIBAPS), Hospital Clinic Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9014-4950","authenticated-orcid":false,"given":"Alejandro","family":"Forner","sequence":"additional","affiliation":[{"name":"Unitat d'Oncologia hep\u00e0tica, Liver Unit, Hospital Cl\u00ednic  Barcelona Spain"},{"name":"BCLC group, IDIBAPS  Barcelona Spain"},{"name":"CIBEREHD  Barcelona Spain"},{"name":"Universitat de Barcelona (UB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9826-0753","authenticated-orcid":false,"given":"Jordi","family":"Bruix","sequence":"additional","affiliation":[{"name":"Unitat d'Oncologia hep\u00e0tica, Liver Unit, Hospital Cl\u00ednic  Barcelona Spain"},{"name":"BCLC group, IDIBAPS  Barcelona Spain"},{"name":"CIBEREHD  Barcelona Spain"},{"name":"Universitat de Barcelona (UB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3795-3705","authenticated-orcid":false,"given":"Marco","family":"Sanduzzi\u2010Zamparelli","sequence":"additional","affiliation":[{"name":"Unitat d'Oncologia hep\u00e0tica, Liver Unit, Hospital Cl\u00ednic  Barcelona Spain"},{"name":"BCLC group, IDIBAPS  Barcelona Spain"},{"name":"CIBEREHD  Barcelona Spain"},{"name":"Universitat de Barcelona (UB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0716-8784","authenticated-orcid":false,"given":"Jos\u00e9","family":"R\u00edos","sequence":"additional","affiliation":[{"name":"Department of Clinical Farmacology Hospital Clinic and Medical Statistics Core Facility, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Biostatistics Unit, Faculty of Medicine, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3919-4135","authenticated-orcid":false,"given":"Mohamed","family":"Bouattour","sequence":"additional","affiliation":[{"name":"AP\u2010HP, H\u00f4pital Beaujon, Liver Cancer Unit  Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3396-6894","authenticated-orcid":false,"given":"Mohamed","family":"El\u2010Kassas","sequence":"additional","affiliation":[{"name":"Endemic Medicine Department Faculty of Medicine Helwan University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassia R. G.","family":"Leal","sequence":"additional","affiliation":[{"name":"Gastroenterology Hospital Universit\u00e1rio Ant\u00f4nio Pedro, Universidade Federal Fuminense  Rio de Janeiro Brazil"},{"name":"Gastroenterology Hospital Federal do Servidores do Estado  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7785-6403","authenticated-orcid":false,"given":"Tudor","family":"Mocan","sequence":"additional","affiliation":[{"name":"3rd Medical Department \"Octavian Fodor\" Institute for Gastroenterology and Hepatology  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4875-9353","authenticated-orcid":false,"given":"Jean\u2010Charles","family":"Nault","sequence":"additional","affiliation":[{"name":"Liver unit H\u00f4pital Avicenne, H\u00f4pitaux Universitaires Paris\u2010Seine\u2010Saint\u2010Denis, Assistance\u2010Publique H\u00f4pitaux de Paris  Bobigny France"},{"name":"Unit\u00e9 de Formation et de Recherche Sant\u00e9 M\u00e9decine et Biologie Humaine Universit\u00e9 Paris Nord, Communaut\u00e9 d'Universit\u00e9s et Etablissements Sorbonne Paris Cit\u00e9  Paris France"},{"name":"Centre de Recherche des Cordeliers Sorbonne Universit\u00e9 Inserm, Equipe labellis\u00e9e Ligue Nationale Contre le Cancer, Labex OncoImmunology. Universit\u00e9 de Paris, team \u00ab Functional Genomics of Solid Tumors  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogerio C. P.","family":"Alves","sequence":"additional","affiliation":[{"name":"Gastroenterology Hospital do Servidor Publico Estadual de S\u00e3o Paulo  Sao Paulo Brazil"},{"name":"Bp Benefic\u00eancia Portuguesa de S\u00e3o Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0359-9795","authenticated-orcid":false,"given":"Helen L.","family":"Reeves","sequence":"additional","affiliation":[{"name":"Liver Unit Newcastle Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"},{"name":"Newcastle University Translational and Clinical Research Institute  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0216-3618","authenticated-orcid":false,"given":"Leonardo","family":"da Fonseca","sequence":"additional","affiliation":[{"name":"Clinical Oncology Sao Paulo Clinicas Liver Cancer Group. Instituto do Cancer do Estado de Sao Paulo. Hospital das Cl\u00ednicas. University of Sao Paulo School of Medicine  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2400-1887","authenticated-orcid":false,"given":"Ignacio","family":"Garc\u00eda\u2010Ju\u00e1rez","sequence":"additional","affiliation":[{"name":"Gastroenterology Department National Institute of Medical Sciences and Nutrition Salvador Zubir\u00e1n  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3529-0103","authenticated-orcid":false,"given":"David J.","family":"Pinato","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4288-2593","authenticated-orcid":false,"given":"Mar\u00eda","family":"Varela","sequence":"additional","affiliation":[{"name":"Liver Unit, Department of Digestive Disease Hospital Universitario Central de Asturias, IUOPA, ISPA, Universidad de Oviedo  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2017-3526","authenticated-orcid":false,"given":"Saleh A.","family":"Alqahtani","sequence":"additional","affiliation":[{"name":"Liver Transplant King Faisal Specialist Hospital &amp; Research Center  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5001-246X","authenticated-orcid":false,"given":"Mario R.","family":"Alvares\u2010da\u2010Silva","sequence":"additional","affiliation":[{"name":"GI\/Liver Unit Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9733-1938","authenticated-orcid":false,"given":"Juan C.","family":"Bandi","sequence":"additional","affiliation":[{"name":"Hepatology Unit Hospital Italiano  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9957-3615","authenticated-orcid":false,"given":"Lorenza","family":"Rimassa","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Rozzano Italy"},{"name":"Medical Oncology and Hematology Unit Humanitas Cancer Center, IRCCS, Humanitas Research Hospital  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7099-0810","authenticated-orcid":false,"given":"Mar","family":"Lozano","sequence":"additional","affiliation":[{"name":"Aparato Digestivo Hospital Universitario Infanta Leonor  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4667-4492","authenticated-orcid":false,"given":"Jes\u00fas M.","family":"Gonz\u00e1lez Santiago","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Salamanca University Clinic Hospital IBSAL, CIBERehd  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-0226","authenticated-orcid":false,"given":"Frank","family":"Tacke","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Salamanca University Clinic Hospital IBSAL, CIBERehd  Salamanca Spain"},{"name":"Department of Hepatology and Gastroenterology Charit\u00e9\u2010Universit\u00e4tsmedizin Campus Virchow\u2010Klinikum and Campus Charit\u00e9 Mitte  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Sala","sequence":"additional","affiliation":[{"name":"Gastroenterology Hepatology Unit Hospital Doctor Josep Trueta, IDIBGI (Institut d'Investigaci\u00f3 Biom\u00e8dica de Girona) CIBERehd  Girona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2238-5322","authenticated-orcid":false,"given":"Mar\u00eda","family":"Anders","sequence":"additional","affiliation":[{"name":"Hospital Aleman Hepatolog\u00eda  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5879-5737","authenticated-orcid":false,"given":"Anja","family":"Lachenmayer","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine Inselspital, Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Pi\u00f1ero","sequence":"additional","affiliation":[{"name":"Liver Unit Hospital Universitario Austral  Pilar Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Medicine Federal University of Sergipe  Aracaju Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0460-4122","authenticated-orcid":false,"given":"Maria","family":"Guarino","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery University of Naples Federico II  Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Elvevi","sequence":"additional","affiliation":[{"name":"Division Gastroenterology and Center for Autoimmune Liver Diseases San Gerardo Hospital University of Milano \u2010 Bicocca School of Medicine  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0946-3859","authenticated-orcid":false,"given":"Giuseppe","family":"Cabibbo","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology and Hepatology PROMISE, University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0597-2728","authenticated-orcid":false,"given":"Markus","family":"Peck\u2010Radosavljevic","sequence":"additional","affiliation":[{"name":"Innere Medizin &amp; 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Instituto Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4835-1259","authenticated-orcid":false,"given":"Chiara","family":"Braconi","sequence":"additional","affiliation":[{"name":"Medical Oncology Beatson West of Scotland Cancer Centre University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4265-5019","authenticated-orcid":false,"given":"Sonia","family":"Pascual","sequence":"additional","affiliation":[{"name":"Liver Unit. HGU Dr. Balmis. CIBERehd. ISABIAL  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0234-2330","authenticated-orcid":false,"given":"Christie","family":"Perell\u00f3","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology University Hospital Puerta de Hierro  Majadahonda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivianne","family":"Mello","sequence":"additional","affiliation":[{"name":"Oncology AMO CLINIC  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6713-8800","authenticated-orcid":false,"given":"Carlos","family":"Rodr\u00edguez\u2010Lope","sequence":"additional","affiliation":[{"name":"Servicio de Aparato Digestivo Hospital Universitario Marqu\u00e9s de Valdecilla IDIVAL  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4507-2422","authenticated-orcid":false,"given":"Juan","family":"Acevedo","sequence":"additional","affiliation":[{"name":"South West Liver Unit University Hospitals Plymouth NHS Trust  Plymouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9875-019X","authenticated-orcid":false,"given":"Rosanna","family":"Villani","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2287-0635","authenticated-orcid":false,"given":"Clemence","family":"Hollande","sequence":"additional","affiliation":[{"name":"AP\u2010HP H\u00f4pital Beaujon, Liver Cancer Unit  Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Vilgrain","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris  Paris France"},{"name":"Department of Radiology H\u00f4pital Beaujon, AP\u2010HP. 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