{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:17:21Z","timestamp":1781741841849,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) has become a major public health problem, but the prevalence of fibrosis associated with non\u2010alcoholic steatohepatitis (NASH) is largely unknown in the general population. This study aimed to provide an updated estimation of the prevalence of NASH fibrosis in Spain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was an observational, retrospective, cross\u2010sectional, population\u2010based study with merged data from two Spanish datasets: a large (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a012\u2009246) population\u2010based cohort (ETHON), including transient elastography (TE) data, and a contemporary multi\u2010centric biopsy\u2010proven NASH cohort with paired TE data from tertiary centres (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0501). Prevalence for each NASH fibrosis stage was estimated by crossing TE data from ETHON dataset with histology data from the biopsy\u2010proven cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From the patients with valid TE in ETHON dataset (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a011\u2009440), 5.61% (95% confidence interval [95% CI]: 2.53\u201011.97) had a liver stiffness measurement (LSM)\u2009\u2265\u20098\u00a0kPa. The proportion attributable to NAFLD (using clinical variables and Controlled Attenuation Parameter) was 57.3% and thus, the estimated prevalence of population with LSM \u2265 8\u00a0kPa because of NAFLD was 3.21% (95% CI 1.13\u20138.75). In the biopsy\u2010proven NASH cohort, 389 patients had LSM \u2265 8\u00a0kPa. Among these, 37% did not have significant fibrosis (F2\u20104). The estimated prevalence of NASH F2\u20103 and cirrhosis in Spain's adult population were 1.33% (95% CI 0.29\u20135.98) and 0.70% (95% CI 0.10\u20134.95) respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These estimations provide an accurate picture of the current prevalence of NASH\u2010related fibrosis in Spain and can serve as reference point for dimensioning the therapeutic efforts that will be required as NASH therapies become available.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15323","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T02:54:08Z","timestamp":1653792848000},"page":"1783-1792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Prevalence estimation of significant fibrosis because of\n                    <scp>NASH<\/scp>\n                    in Spain combining transient elastography and histology"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2265-6591","authenticated-orcid":false,"given":"Jos\u00e9 L.","family":"Calleja","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hospital Universitario Puerta de Hierro, School of Medicine, Universidad Aut\u00f3noma Madrid, IDIPHIM  Majadahonda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4357-8817","authenticated-orcid":false,"given":"Jes\u00fas","family":"Rivera\u2010Esteban","sequence":"additional","affiliation":[{"name":"Liver Unit Vall d'Hebron Hospital Universitari, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus  Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona  Bellaterra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Aller","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Clinic University Hospital, Medical School, Group of Biomedical Research in Critical Care Medicine (BioCritic), University of Valladolid  Valladolid Spain"},{"name":"Research Unit Clinic University Hospital, Medical School, Institute of Health Sciences of Castille and Leon (IECSCYL), Group of Biomedical Research in Critical Care Medicine (BioCritic)  Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7153-0493","authenticated-orcid":false,"given":"Marta","family":"Hern\u00e1ndez\u2010Conde","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Hospital Universitario Puerta de Hierro, School of Medicine, Universidad Aut\u00f3noma Madrid, IDIPHIM  Majadahonda 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(BioCritic)  Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Serra","sequence":"additional","affiliation":[{"name":"Digestive Medicine Service Clinic University Hospital, University of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amparo","family":"Escudero","sequence":"additional","affiliation":[{"name":"Digestive Medicine Service Clinic University Hospital, University of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8332-2122","authenticated-orcid":false,"given":"Javier","family":"Ampuero","sequence":"additional","affiliation":[{"name":"Digestive Diseases Department and CIBERehd Virgen del Roc\u00edo University Hospital, Institute of Biomedicine of Seville, University of Seville  Seville 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