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The aetiology of liver failure varies in different countries at different times. Viruses (Hepatitis A, B and E), drugs (herbs and anti\u2010tuberculous drugs), toxins (alcohol use) and autoimmune flares are mainly responsible of majority of liver failure in individuals with normal liver (acute liver failure; ALF); else these may precipitate liver failure in those with chronic liver disease (acute\u2010on\u2010chronic liver failure; ACLF). Concomitant increases in alcohol misuse and metabolic syndrome in recent years are concerning. Ongoing efforts to address liver failure\u2010related morbidity and mortality require accurate contemporary estimates of epidemiology and outcomes. In light of the ever\u2010changing nature of liver disease epidemiology, accurate estimates for the burden of liver failure across the countries are vital for setting clinical, research and policy priorities. In this review, we aimed to describe the current as well as changing epidemiological trends of common liver failure syndromes, ALF and ACLF in the Asia\u2010Pacific region.<\/jats:p>","DOI":"10.1111\/liv.15328","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T11:12:20Z","timestamp":1653909140000},"page":"2093-2109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Epidemiology of liver failure in <scp>Asia\u2010Pacific<\/scp> region"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5582-7759","authenticated-orcid":false,"given":"Ankur","family":"Jindal","sequence":"first","affiliation":[{"name":"Department of Hepatology Institute of Liver and Biliary Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0544-5610","authenticated-orcid":false,"given":"Shiv 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