{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:15:52Z","timestamp":1785410152108,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Advances in hepatitis B virus (HBV) and hepatitis C virus (HCV) therapies have improved morbidity and mortality, but global disparities in viral hepatitis outcomes remain. We evaluate global trends in the impact of HBV and HCV on disability\u2010adjusted life years (DALYs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using data from the 2010\u20132019 Global Burden of Diseases Study (GBD), overall all\u2010cause DALYs for patients with acute HBV or HCV, HBV\u2010 or HCV\u2010related cirrhosis, and HBV\u2010 or HCV\u2010related hepatocellular carcinoma (HCC) was calculated as the sum of years of life lost because of premature death and years lived with disability. DALYs were presented as age\u2010standardized rates per 100\u2009000 population stratified by age and sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 2010 to 2019, the overall global impact of HBV on DALYs per 100\u2009000 decreased from 27.6 to 20.9 for acute HBV and 168.6 to 129.8 for HBV\u2010related cirrhosis but remained stable for HBV\u2010related HCC. The impact of HCV on DALYs per 100\u2009000 decreased from 5.23 to 3.3 for acute HCV, 159.2 to 146.2 for HCV\u2010related cirrhosis, and 37.5 to 34.9 for HCV\u2010related HCC. We observed significant differences in the impact of HBV and HCV on DALYs when stratified by world regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Decreases in HBV and HCV DALYs from 2010 to 2019 were observed. Disparities in DALY improvements across world regions suggest unequal access to viral hepatitis care and treatment. Achieving goals of viral hepatitis elimination will require enhanced prevention efforts and funding for high\u2010burden regions and regions that have not had substantial reductions in DALYs because of HBV and HCV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15347","type":"journal-article","created":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T17:33:54Z","timestamp":1656264834000},"page":"2145-2153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Global trends and the impact of chronic hepatitis B and C on <scp>disability\u2010adjusted<\/scp> life years"],"prefix":"10.1111","volume":"42","author":[{"given":"Nicolette","family":"Veracruz","sequence":"first","affiliation":[{"name":"Central Michigan University College of Medicine  Saginaw Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6306-3189","authenticated-orcid":false,"given":"Robert G.","family":"Gish","sequence":"additional","affiliation":[{"name":"Hepatitis B Foundation  Doylestown Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0211-7013","authenticated-orcid":false,"given":"Ramsey","family":"Cheung","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Veterans Affairs Palo Alto Healthcare System  Palo Alto California USA"},{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit S.","family":"Chitnis","sequence":"additional","affiliation":[{"name":"Tuberculosis Section, Division of Communicable Disease Control and Prevention Alameda County Public Health Department  San Leandro California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8923-2806","authenticated-orcid":false,"given":"Robert J.","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Veterans Affairs Palo Alto Healthcare System  Palo Alto California USA"},{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.04.035"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-014-0145-y"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.09.014"},{"key":"e_1_2_11_5_1","unstructured":"World Health Organization.Global Health Sector Strategies on Viral Hepatitis 2016\u20102021. 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