{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:25Z","timestamp":1787015725998,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hepatorenal syndrome\u2010acute kidney injury (HRS\u2010AKI) is a serious complication of severe liver disease with a clinically poor prognosis. Supportive care using vasoconstrictors and intravenous albumin are the current mainstays of therapy. Terlipressin is an efficacious vasoconstrictor that has been used for 2 decades as the first\u2010line treatment for HRS\u2010AKI in Europe and has demonstrated greater efficacy in improving renal function compared to placebo and other vasoconstrictors. One of the challenges associated with terlipressin use is monitoring and mitigating serious adverse events, specifically adverse respiratory events, which were noted in a subset of patients in the recently published CONFIRM trial, the largest randomized trial examining terlipressin use for HRS\u2010AKI. In this article, we review terlipressin's pharmacology, hypothesize how its mechanism contributes to the risk of respiratory compromise and propose strategies that will decrease the frequency of these events by rationally selecting patients at lower risk for these events.<\/jats:p>","DOI":"10.1111\/liv.15367","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T09:23:35Z","timestamp":1657877015000},"page":"2124-2130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Respiratory events with terlipressin and albumin in hepatorenal syndrome: A review and clinical guidance"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9416-6623","authenticated-orcid":false,"given":"Andrew S.","family":"Allegretti","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram M.","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Divisions of Gastroenterology and Hepatology and Pulmonary and Critical Care Medicine, Department of Medicine Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7391-8507","authenticated-orcid":false,"given":"Claire","family":"Francoz","sequence":"additional","affiliation":[{"name":"Hepatology and Liver Intensive Care Unit, Hospital Beaujon  Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody C.","family":"Olson","sequence":"additional","affiliation":[{"name":"Divisions of Gastroenterology, Hepatology, Pulmonary and Critical Care Medicine University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0764-7873","authenticated-orcid":false,"given":"Andr\u00e9s","family":"C\u00e1rdenas","sequence":"additional","affiliation":[{"name":"GI and Liver Unit, Institut de Malalties Digestives, Hospital Cl\u00ednic, Barcelona, Spain. Institut d'Investigacions Biom\u00e8diques August Pi\u2010Sunyer (IDIBAPS), Barcelona and Ciber de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.07.043"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.12.029"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.107789"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.024"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/jep.S146034"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0B013E31819B8199"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90734-3"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107466"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.026"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.014"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2008290"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31884"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005162.pub4"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013103.pub2"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41581-019-0218-4"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0B013E32833A4822"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/HEP.1840150511"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30208"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27709"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.33160"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15836"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfz048"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMA.2013.13805"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.066118"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11894-020-00783-1"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14052"},{"key":"e_1_2_14_28_1","unstructured":"Food and Drug Administration.FDA Briefing Document. Cardiovascular and Renal Drugs Advisory Committee Meeting. July 15 2020. NDA 22231 Terlipressin.https:\/\/www.fda.gov\/media\/139963\/download"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032193"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/2048872612457087"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CGH.2018.01.035"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1916062"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26359"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2022166"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.35819"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28396"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1053\/J.AJKD.2020.03.016"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/LT.26344"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.15367","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/liv.15367","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.15367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T09:07:57Z","timestamp":1692608877000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.15367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,3]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/liv.15367"],"URL":"https:\/\/doi.org\/10.1111\/liv.15367","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,3]]},"assertion":[{"value":"2022-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}