{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:23:46Z","timestamp":1790033026422,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Achieving Hepatitis B e antigen seroconversion (HBeAg SC) at an earlier age confers a better prognosis. We examined baseline and post\u2010partum factors associated with HBeAg SC after pregnancy. We developed a tool, the SydPregScore, to estimate the likelihood of HBeAg SC in the years after pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis of an HBeAg\u2010positive pregnant cohort was conducted. Variables including baseline age, parity, alanine aminotransferase level, HBV viral load, quantitative HBsAg, use of antiviral therapy and post\u2010partum flare were collected. Univariate and multivariate Cox regression analyses to determine predictors of HBeAg SC and develop a predictor score were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We analysed HBeAg SC rates in 220 pregnancies to 149 HBeAg\u2010positive women from 2006 to 2019. At baseline, their median age was 33 (IQR 29\u201337), ALT 23\u2009U\/L (IQR 17\u201333) and viral load 8 log\n                      <jats:sub>10<\/jats:sub>\n                      IU\/mL (IQR 6.3\u20138.2 log\n                      <jats:sub>10<\/jats:sub>\n                      IU\/mL). The majority (133\/198, 67.2%) received short\u2010course antiviral therapy to prevent mother\u2010to\u2010child transmission, and 109\/192 (56.8%) had a post\u2010partum flare. HBeAg SC occurred in 74\/220 (33.6%) after pregnancy (median follow\u2010up 814\u2009days, IQR 405\u20131531). Multivariate analysis identified baseline viral load &lt;8 log\n                      <jats:sub>10<\/jats:sub>\n                      IU\/mL (HR 2.426 [1.224\u20134.809], p = .011), baseline ALT \u22652 ULN (HR 2.726 [1.299\u20135.721],\n                      <jats:italic>p<\/jats:italic>\n                      = .008) and age &lt;35 (HR 2.859 [1.255\u20136.513], p = .012) to be positive predictors of HBeAg SC. The \u2018SydPreg Score\u2019 estimated the probability of HBeAg SC at 2000\u2009days as 10%, 30%, 70% and 80% for 0, 1, 2, and 3 predictors respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The SydPreg Score allows the prediction of HBeAg SC in the years after pregnancy. Even in those without elevated ALT, age &lt;35 and viral load &lt;8 log\n                      <jats:sub>10<\/jats:sub>\n                      IU\/mL can identify women with a good chance of subsequent HBeAg SC. Those without a chance may benefit from viral suppression.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15372","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T07:38:42Z","timestamp":1658389122000},"page":"69-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Predicting hepatitis B e Antigen seroconversion after pregnancy\u2014The\n                    <scp>SydPregScore<\/scp>"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2780-7643","authenticated-orcid":false,"given":"Cynthuja","family":"Thilakanathan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Liverpool Hospital  Sydney Australia"},{"name":"South Western Sydney Clinical School University of New South Wales Sydney, Liverpool  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8927-3635","authenticated-orcid":false,"given":"Tahrima","family":"Kayes","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Liverpool Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Di Girolamo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Liverpool Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"South Western Sydney Clinical School University of New South Wales Sydney, Liverpool  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Glass","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Liverpool Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sicha","family":"Manandhar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Liverpool Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Lawler","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Bankstown Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Meredith","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Bankstown Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Maley","sequence":"additional","affiliation":[{"name":"South Western Sydney Clinical School University of New South Wales Sydney, Liverpool  Sydney Australia"},{"name":"Sydney South West Pathology Service Liverpool Hospital  Sydney 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(2019).Management of hepatitis B in pregnancy. 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