{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T10:06:35Z","timestamp":1777111595228,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Liver transplantation (LT) is the treatment of end\u2010stage non\u2010alcoholic liver disease (NAFLD), that is decompensated cirrhosis and\/or complicated by hepatocellular carcinoma (HCC). Few data on long\u2010term outcome are available. The aim of this study was to evaluate overall patient and graft survivals and associated predictive factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This retrospective multicentre study included adult transplant patients for NAFLD cirrhosis between 2000 and 2019 in participating French\u2010speaking centres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 361 patients (69.8% of male) were included in 20 centres. The median age at LT was 62.3\u2009years [57.4\u201365.9] and the median MELD score was 13.9 [9.1\u201321.3]; 51.8% of patients had HCC on liver explant. Between 2004 and 2018, the number of LT for NAFLD cirrhosis increased by 720%. A quarter of the patients had cardiovascular history before LT. Median follow\u2010up after LT was 39.1\u00a0months [15.8\u201372.3]. Patient survival at 1, 5 and 10\u2009years after LT was 89.3%, 79.8% and 68.1% respectively. The main causes of death were sepsis (37.5%), malignancies (29.2%) and cardiovascular events (22.2%). In multivariate analysis, three risk factors for overall mortality after LT were recipient pre\u2010LT BMI\u2009&lt;\u200932\u2009kg\/m<jats:sup>2<\/jats:sup> at LT time (OR: 2.272; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.012), pre\u2010LT angioplasty during CV check\u2010up (OR: 2.916; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.016), a combined donor and recipient age over 135\u2009years (OR: 2.020; 95%CI: <jats:italic>p<\/jats:italic>\u00a0=\u00a0.035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Survival after LT for NAFLD cirrhosis is good at 5\u2009years. Donor and recipient age, and cardiovascular history, are major prognostic factors to consider.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15385","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T08:09:57Z","timestamp":1659600597000},"page":"2428-2441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Liver transplantation for <scp>NAFLD<\/scp> cirrhosis: Age and recent coronary angioplasty are major determinants of survival"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9327-4590","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Villeret","sequence":"first","affiliation":[{"name":"Service d'h\u00e9patologie et de transplantation h\u00e9patique H\u00f4pital de la Croix Rousse, Hospices Civils de Lyon  Lyon France"},{"name":"Universit\u00e9 Claude Bernard Lyon 1  Lyon 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