{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:26:33Z","timestamp":1770042393128,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In July 2020, the entry inhibitor bulevirtide was approved in the European Union for the treatment of chronic hepatitis delta virus (HDV) infection. We describe the first 48\u2009weeks of bulevirtide therapy in eight patients (<jats:italic>n<\/jats:italic>\u00a0=\u20097 male, <jats:italic>n<\/jats:italic>\u00a0=\u20091 female; <jats:italic>n<\/jats:italic>\u00a0=\u20093 compensated cirrhosis) treated at our centre. Median ALT values declined from 82 to 34\u2009U\/L after 48\u2009weeks. Median HDV RNA dropped from 13\u2009380\u2009000 to 3135\u2009copies\/ml. One patient showed no significant response and was discontinued at week 16. Overall, we observed a favourable safety profile and a marked biochemical and virological response in the majority of our patients.<\/jats:p>","DOI":"10.1111\/liv.15408","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T08:04:06Z","timestamp":1661414646000},"page":"2403-2407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Real\u2010life experiences with bulevirtide for the treatment of hepatitis delta\u201448\u00a0weeks data from a German centre"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2215-4815","authenticated-orcid":false,"given":"Caroline","family":"Z\u00f6llner","sequence":"first","affiliation":[{"name":"Department of Hepatology and Gastroenterology Charit\u00e9 Universit\u00e4tsmedizin Berlin, Campus Virchow\u2010Klinikum (CVK) and Campus Charit\u00e9 Mitte (CCM)  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3966-515X","authenticated-orcid":false,"given":"J\u00f6rg","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Institute of Virology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Lutz","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Charit\u00e9 Universit\u00e4tsmedizin Berlin, Campus Virchow\u2010Klinikum (CVK) and Campus Charit\u00e9 Mitte (CCM)  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-0226","authenticated-orcid":false,"given":"Frank","family":"Tacke","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Charit\u00e9 Universit\u00e4tsmedizin Berlin, Campus Virchow\u2010Klinikum (CVK) and Campus Charit\u00e9 Mitte (CCM)  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7050-797X","authenticated-orcid":false,"given":"M\u00fcnevver","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Charit\u00e9 Universit\u00e4tsmedizin Berlin, Campus Virchow\u2010Klinikum (CVK) and Campus Charit\u00e9 Mitte (CCM)  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-013-0365-x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.04.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316601"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30663-7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.04.016"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13235"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","unstructured":"WedemeyerH BogomolovP BlankA et al.Final results of a multicenter open\u2010label phase 2b clinical trial to assess safety and efficacy of Myrcludex B in combination with Tenofovir in patients with chronic HBV\/HDV co\u2010infection; 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