{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:36:16Z","timestamp":1790858176202,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012449","name":"Southern University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and aims<\/jats:title><jats:p>Epidemiological evidence regarding the association of air pollution with the risk of non\u2010alcoholic fatty liver disease (NAFLD) is limited. This study was to examine the associations of long\u2010term exposure to various air pollutants and overall air pollution with risk of incident NAFLD as well as cirrhosis, a major liver\u2010related morbidity for NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Included were 456\u2009687 UK residents. Air pollution data included PM<jats:sub>2.5<\/jats:sub>, PM<jats:sub>2.5\u201310<\/jats:sub>, PM<jats:sub>10<\/jats:sub>, NO<jats:sub>2<\/jats:sub> and NO<jats:sub>x<\/jats:sub>. A weighted air pollution score was also generated from PM<jats:sub>10<\/jats:sub> and NO<jats:sub>x<\/jats:sub>. Cox proportional hazard models were employed to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 4978 cases of NAFLD and 1575 cases of incident cirrhosis, over a median follow\u2010up of 11.9\u2009years. PM<jats:sub>2.5<\/jats:sub>, PM<jats:sub>10<\/jats:sub>, NO<jats:sub>2<\/jats:sub> and NO<jats:sub>x<\/jats:sub> exposures contributed to the excess risk of NAFLD associated with air pollution score; and the corresponding adjusted HRs (95% CI) were 1.10 (1.05, 1.14), 1.14 (1.09, 1.20), 1.19 (1.13, 1.24) and 1.11 (1.07, 1.15), respectively, for each interquartile range increase in the above specific air pollutants. Similar patterns were also indicated for cirrhosis risk. Alcohol consumption was an effect modifier for the association between air pollution score and NAFLD risk, whereas body mass index modified the association for cirrhosis risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Long\u2010term exposure to air pollution was associated with risks of NAFLD and cirrhosis among the UK population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15416","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T13:24:29Z","timestamp":1662557069000},"page":"299-307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Long\u2010term exposure to air pollution and incident non\u2010alcoholic fatty liver disease and cirrhosis: A cohort study"],"prefix":"10.1111","volume":"43","author":[{"given":"Fu\u2010Rong","family":"Li","sequence":"first","affiliation":[{"name":"Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine 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