{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:44:37Z","timestamp":1790649877961,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000046","name":"Abbott Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Fatigue among patients with NAFLD may negatively impact their health\u2010related quality of life and clinical outcomes (mortality). We determined fatigue prevalence and its association with all\u2010cause mortality among patients with NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>NHANES 2005\u20132010 and 2017\u20132018 data were used with linked mortality data. NAFLD was defined by fatty liver index for NHANES 2005\u20132010 and by transient elastography for NHANES 2017\u20132018. Fatigue was assessed by Patient Health Questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NHANES 2005\u20132010 cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a05429, mean age 47.1\u2009years, 49.7% male, 69.9% white), 37.6% had NAFLD. Compared to non\u2010NAFLD controls, fatigue was more common in NAFLD (8.35% vs 6.0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002). Among NHANES 2017\u20132018 cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a03830, mean age 48.3\u2009years, 48.6% male, 62.3% white), 36.9% had NAFLD. Compared to non\u2010NAFLD controls, fatigue was more common among NAFLD (8.7% vs 6.2%). NAFLD had more sleep disturbance (34.0% vs 26.7%), cardiovascular disease (CVD) (10.7% vs. 6.3%), significant hepatic fibrosis (liver stiffness&gt;8.0\u00a0kPa, 17.9% vs 3.5%) and advanced hepatic fibrosis (&gt;13.1\u00a0kPa, 5.4% vs 0.9%; all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.003). The presence of depression (OR: 11.52, 95% CI: 4.45\u201329.80, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001), CVD (OR: 3.41, 95% CI: 1.02\u201311.34, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0462) and sleep disturbance (OR: 2.00, 95% CI: 1.00\u20133.98, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0491) was independently associated with fatigue; good sleep quality (OR: 0.58, 95% CI: 0.35\u20130.96, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0366) had an inverse association. By multivariable Cox model, NAFLD adults with fatigue experienced 2.3\u2010fold higher mortality than NAFLD without fatigue (HR: 2.31, 95% CI: 1.37\u20133.89, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fatigue among those with NAFLD is associated with increased risk for mortality and is mainly driven by depression, sleep disturbance and CVD. These findings have important clinical implications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15437","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T16:10:07Z","timestamp":1664208607000},"page":"2646-2661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The impact of fatigue on mortality of patients with non\u2010alcoholic fatty liver disease: Data from National Health and nutrition examination survey 2005\u20132010 and 2017\u20132018"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9313-577X","authenticated-orcid":false,"given":"Zobair M.","family":"Younossi","sequence":"first","affiliation":[{"name":"Betty and Guy Beatty Center for Integrated Research Inova Health System  Falls Church Virginia USA"},{"name":"Center for Liver Disease, Department of Medicine Inova Fairfax Medical Campus  Falls Church Virginia USA"},{"name":"Inova 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