{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:26:53Z","timestamp":1787239613697,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260396"],"award-info":[{"award-number":["82260396"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960370"],"award-info":[{"award-number":["81960370"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004467","name":"Program for Innovative Research Team of Ningbo Novel Photoelectric Materials and Devices","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004467","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatitis E virus (HEV) infection causes serious adverse pregnancy outcomes during pregnancy. However, the maternal and fetal damage induced by HEV infection is rarely reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A BALB\/c pregnant mouse model was established to explore the maternal and fetal pathological damage and inflammatory responses caused by HEV infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Notably, miscarriages and stillbirths were observed in HEV\u2010infected pregnant mice. HEV infections were identified by qRT\u2010PCR, immunohistochemical analysis and immunofluorescence assay in the uterus, placenta, umbilical cords and livers and brains of fetuses. Serious inflammatory responses and pathological damage were triggered in the uterus and placenta of HEV\u2010infected pregnant mice. Vertical transmission of HEV resulted in severe pathological damage and inflammatory responses in the livers and brains of fetuses, as well as emerging apoptosis cells in the brains of fetuses. Most of the cytokines\/chemokines in the sera were significantly increased in the HEV\u2010infected pregnant mice. Remarkably, cytokines\/chemokines were significantly different between HEV\u2010infected pregnant and miscarriage mice; IL9, GM\u2010CSF and IL1\u03b1 were the most important three cytokines\/chemokines in determining the pregnancy outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HEV infections cause serious maternal\/fetal pathological damage, inflammatory responses and apoptosis, which may be responsible for adverse pregnancy outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.15468","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T04:54:19Z","timestamp":1666932859000},"page":"317-328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Severe maternal\u2013fetal pathological damage and inflammatory responses contribute to miscarriage caused by hepatitis E viral infection during pregnancy"],"prefix":"10.1111","volume":"43","author":[{"given":"Yueping","family":"Xia","sequence":"first","affiliation":[{"name":"Life Science and Technology &amp; Medical Faculty Kunming University of Science and Technology  Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Yang","sequence":"additional","affiliation":[{"name":"Life Science and Technology &amp; Medical Faculty Kunming University of Science and Technology  Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Life Science and Technology &amp; Medical Faculty Kunming University of Science and Technology  Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyao","family":"Qian","sequence":"additional","affiliation":[{"name":"Life Science and 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