{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:03:48Z","timestamp":1791302628486,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070631"],"award-info":[{"award-number":["82070631"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>The definitive treatment for pyrrolizidine alkaloids (PAs)\u2010induced hepatic sinusoidal obstruction syndrome (HSOS) is not available. The effectiveness of anticoagulation therapy remains controversial. The efficacy of low molecular weight heparin (LMWH) should be investigated in patients and animal models, and the underlying mechanism should be explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The prognosis of patients with PAs\u2010HSOS who received anticoagulation therapy was retrospectively analysed. The effect of enoxaparin on the liver injury was determined in animal models of monocrotaline (MCT)\u2010induced HSOS was determined, and the underlying mechanism was investigated using a murine model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cumulative survival rate of patients with PAs\u2010induced HSOS was 60.00% and 90.90% in the non\u2010anticoagulation group and anticoagulation group. Enoxaparin attenuated liver injury effectively in a rat model of MCT\u2010induced HSOS. Additionally, the improvement of severe liver injury was observed in MCT\u2010treated mice after the administration of enoxaparin (40\u2009mg\/kg). The alleviation of liver injury was observed in mice with hepatocyte\u2010specific deletion of oncostatin M (Osm<jats:sup>\u25b3Hep<\/jats:sup>). In MCT\u2010treated mice administrated with enoxaparin, no significant differences in liver injury were observed between Osm<jats:sup>\u25b3Hep<\/jats:sup> mice and Osm<jats:sup>flox\/flox<\/jats:sup> mice. Additionally, adenovirus\u2010mediated overexpression of Osm resulted in severe liver injury in MCT\u2010induced mice after the administration of enoxaparin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LMWH attenuated severe liver injury in patients with PAs\u2010Induced HSOS and animal models of MCT\u2010induced HSOS, which provides a rationale for the application of anticoagulation therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15475","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T13:34:48Z","timestamp":1668087288000},"page":"626-638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Enoxaparin attenuates pyrrolizidine alkaloids\u2010induced hepatic sinusoidal obstruction syndrome by inhibiting oncostatin M expression"],"prefix":"10.1111","volume":"43","author":[{"given":"Hongyu","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuanglong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan 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