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Fatty liver disease and steatohepatitis similarly occur in individuals who have both metabolic syndrome and excessive alcohol intake; therefore, the single overarching term metabolic associated fatty liver disease (MAFLD) has been proposed to better reflect these risk factors and the continuity of disease progression. Extracellular vesicles (EVs) are membrane\u2010bound endogenous nanoparticles released into the extracellular space by a majority of cell types. Liver disease\u2010related EVs contain a variety of cellular cargo and are internalized into target cells resulting in the transfer of bioinformation reflecting the state of the donor cell to the recipient. Furthermore, EV composition can be used to identify the degree and type of liver disease, suggesting that EV composition may be a useful biomarker. With regard to MAFLD, the presence of metabolic risk factors, such as insulin resistance, will be indicated by adipose tissue\u2010derived EVs and with that comes the potential to use as a clinical monitor of overall metabolic status. However, the inhibition of specific EV composition may be difficult to implement as a real\u2010world therapeutic approach. Current global evidence shows that mesenchymal stem cell (MSCs)\u2010derived EVs (MSC\u2010EVs) play an important role in regulating the immune response, which has spawned a clinical trial to treat liver disease.<\/jats:p>","DOI":"10.1111\/liv.15490","type":"journal-article","created":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T16:39:39Z","timestamp":1670085579000},"page":"292-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Extracellular vesicles in fatty liver disease and steatohepatitis: Role as biomarkers and therapeutic targets"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0555-2707","authenticated-orcid":false,"given":"Akiko","family":"Eguchi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Graduate School of Medicine Mie University  Tsu 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