{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:59:47Z","timestamp":1790200787867,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Autoimmune hepatitis (AIH) is a rare indication (&lt;5%) for liver transplantation (LT). The aim of this study was to describe the early outcome after LT for AIH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter retrospective nationwide study including all patients aged \u226516 transplanted for AIH in France was conducted. Occurrences of biliary and vascular complications, rejection, sepsis, retransplantation and death were collected during the first year after LT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 344 patients (78.8% of women, 17.0% of (sub)fulminant hepatitis and 19.2% of chronic liver diseases transplanted in the context of acute\u2010on\u2010chronic liver failure [ACLF]) were included, with a median age at LT of 43.6\u2009years. Acute rejection, sepsis, biliary and vascular complications occurred in respectively 23.5%, 44.2%, 25.3% and 17.4% of patients during the first year after LT. One\u2010year graft and patient survivals were 84.3% and 88.0% respectively. The main cause of early death was sepsis. Pre\u2010LT immunosuppression was not associated with an increased risk for early infections or surgical complications. Significant risk factors for septic events were LT in the context of (sub)fulminant hepatitis or ACLF, acute kidney injury at the time of LT (AKI) and occurrence of biliary complications after LT. AKI was the only independent factor associated with graft (HR\u00a0=\u00a02.5; 95% CI: 1.1\u20135.4; <jats:italic>p<\/jats:italic>\u00a0=\u2009.02) and patient survivals (HR\u00a0=\u00a02.6; 95% CI: 1.0\u20136.5; <jats:italic>p<\/jats:italic>\u00a0=\u2009.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early prognosis is good after LT for AIH and is not impacted by pre\u2010LT immunosuppression but by the presence of AKI at the time of LT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15500","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T03:04:06Z","timestamp":1672283046000},"page":"906-916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Liver transplantation for autoimmune hepatitis: Pre\u2010transplant does not predict the early post\u2010transplant outcome"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7548-3703","authenticated-orcid":false,"given":"Yasmina","family":"Chouik","sequence":"first","affiliation":[{"name":"Hospices civils de Lyon, H\u00f4pital Edouard Herriot, et Universit\u00e9 Claude Bernard Lyon 1  Lyon France"},{"name":"Service d'H\u00e9pato\u2010Gastroent\u00e9rologie Hospices civils de Lyon, H\u00f4pital de la Croix Rousse  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7391-8507","authenticated-orcid":false,"given":"Claire","family":"Francoz","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9patologie et Transplantation H\u00e9patique APHP, H\u00f4pital Beaujon, Universit\u00e9 Paris Diderot, INSERM U1149  Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"De\u00a0Martin","sequence":"additional","affiliation":[{"name":"Centre H\u00e9pato\u2010Biliaire, Centre de R\u00e9f\u00e9rence Maladies Inflammatoires des Voies Biliaires et H\u00e9patites Auto\u2010immunes Inserm Unit\u00e9 1193, AP\u2010HP H\u00f4pital Paul\u2010Brousse, Universit\u00e9 Paris\u2010Saclay, FHU H\u00e9patinov  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Guillaud","sequence":"additional","affiliation":[{"name":"Hospices civils de Lyon, H\u00f4pital Edouard Herriot, et Universit\u00e9 Claude Bernard Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armand","family":"Abergel","sequence":"additional","affiliation":[{"name":"CHU Estaing, M\u00e9decine digestive, Institut Pascal., UMR 6602 UCA CNRS SIGMA  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Altieri","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9pato\u2010Gastroent\u00e9rologie, Nutrition et Oncologie Digestive 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