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We applied the recently proposed Fibrotic NASH Index (FNI) to estimate trends in the prevalence of probable fibrotic NASH in the general United States population using data from the 1999\u20132016\u2009cycles of the National Health and Nutrition Examination Survey. A total of 40\u2009273 participants aged 20\u2009years and older were included in the analysis. The prevalence of probable fibrotic NASH (FNI \u22650.33) in the overall population was 8.4% (95% CI 8.0\u20138.8), with higher values found in males and in Hispanic participants. It increased from 6.9% (95% CI 6.3\u20137.6) in 1999\u20132004 to 9.2% (95% CI 8.4\u201310.0) in 2011\u20132016. This positive trend was evident in both sexes and in participants with obesity and diabetes. Finally, it increased progressively with increasing age, body mass index and worse glucose tolerance. NASH prevalence is increasing in the general US population, synchronous with increasing rates of obesity and type 2 diabetes.<\/jats:p>","DOI":"10.1111\/liv.15503","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T08:13:20Z","timestamp":1671869600000},"page":"340-344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Trends in prevalence of probable fibrotic non\u2010alcoholic steatohepatitis in the United States, 1999\u20132016"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2422-3041","authenticated-orcid":false,"given":"Stefano","family":"Ciardullo","sequence":"first","affiliation":[{"name":"Department of Medicine and Rehabilitation Policlinico di Monza  Monza Italy"},{"name":"Department of Medicine and Surgery University of Milano Bicocca  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3024-0457","authenticated-orcid":false,"given":"Gianluca","family":"Perseghin","sequence":"additional","affiliation":[{"name":"Department of Medicine and Rehabilitation Policlinico di Monza  Monza Italy"},{"name":"Department of Medicine and Surgery University of Milano Bicocca  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14828"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01377.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0144-8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30383-8"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.03.044"},{"key":"e_1_2_10_7_1","unstructured":"National Center for Health Statistics.National Health and Nutrition Examination Survey 2017\u20102018 Laboratory Data. 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