{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:58:29Z","timestamp":1775473109808,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170604"],"award-info":[{"award-number":["82170604"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Heavy drinking is a primary cause of alcoholic liver injury (ALI). Pituitary tumour transforming gene 1 (PTTG1) is involved in the occurrence and development of hepatocellular carcinoma (HCC), which is a well\u2010known inflammation\u2010related cancer with various aetiologies, including alcohol consumption. However, the role of PTTG1 in alcohol\u2010induced liver injury and inflammation is not clear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Blood samples were collected from patients with acute alcohol intoxication (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) and healthy controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a020). PTTG1 knockout (KO) mice and PTTG1 transgenic (TG) mice were given a single gavage of alcohol (5\u00a0g\/kg, 50%) to construct the alcohol\u2010induced liver injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that serum PTTG1 levels were downregulated in acute ALI patients. In addition, acute alcohol administration significantly reduced PTTG1 levels in the serum and liver of mice. Compared to wild\u2010type mice, PTTG1 KO mice had more serious liver injury, which was accompanied by worsened hepatic endoplasmic reticulum (ER) stress and hepatocyte pyroptosis induced by alcohol. Similarly, PTTG1 deficiency exacerbated alcohol\u2010induced cell death in primary mouse hepatocytes and LO2 cells, by increasing hepatic ER stress and pyroptosis. Importantly, TUDCA, an ER stress inhibitor, could blocked alcohol\u2010induced hepatic pyroptosis in PTTG1 knockdown LO2 cells. Finally, overexpression of PTTG1 substantially attenuated alcohol\u2010induced liver injury by reducing ER stress and hepatic pyroptosis in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We demonstrated that PTTG1 participates in ALI and has a protective effect against alcohol\u2010induced hepatic ER stress and pyroptosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.15535","type":"journal-article","created":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T04:52:56Z","timestamp":1675486376000},"page":"840-854","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["PTTG1 alleviates acute alcoholic liver injury by inhibiting endoplasmic reticulum stress\u2010induced hepatocyte pyroptosis"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9931-0695","authenticated-orcid":false,"given":"Shiuan","family":"Tien","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Liver Disease Research  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3781-5241","authenticated-orcid":false,"given":"Haoxiong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Liver Disease Research  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The 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